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Clinical Trials in China / NCT06558227
Recruiting Phase 2

Study of ZG005 Combined With Bevacizumab Versus Sintilimab Combined With Bevacizumab in Advanced Hepatocellular Carcinoma

NCT06558227 · tracked via the Priya Life Science China tracker
Sponsor
Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Phase
Phase 2
Started
2024-10-24
Last updated
2024-12-16

Condition(s) studied

Hepatocellular Carcinoma

Investigational drug(s) / intervention(s)

ZG005 for InjectionBevacizumabSintilimabBevacizumab

ZG005 for Injection: 10 mg/kg or 20 mg/kg administered intravenously Q3w

Bevacizumab: 15 mg/kg administered intravenously Q3w

Sintilimab: 200 mg administered intravenously Q3w

Bevacizumab: 15 mg/kg administered intravenously Q3w

Study summary

This study is a randomized, open-label, positive-controlled, multicenter phase II clinical trial. It evaluates the efficacy and safety of ZG005 combined with Bevacizumab compared to Sintilimab combined with Bevacizumab in first-line treatment for patients with advanced hepatocellular carcinoma.

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: * Fully understand the study and voluntarily sign the informed consent form. * 18-75 years of age; * Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1; * Life expectancy ≥ 12 weeks. Exclusion Criteria: * Patients were deemed unsuitable for participating in the study by the investigator for any reasons.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
West China Hospital of Sichuan University Chengdu Sichuan Recruiting

On this site

📄 Avastin (bevacizumab) drug profile →

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06558227 on ClinicalTrials.gov ↗ ← All trials in China