Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG

NCT06524479 · tracked via the Priya Life Science China tracker

Sponsor

Xuanwu Hospital, Beijing

Phase

Not applicable

Started

2024-07-08

Last updated

2025-06-27

Condition(s) studied

Refractory EpilepsySleep

Investigational drug(s) / intervention(s)

SEEG recordings and SPES

SEEG recordings and SPES: This study will utilize stereoelectroencephalography (SEEG) recordings combined with single-pulse electrical stimulation (SPES) to investigate functional brain connectivity and cortical excitability patterns in patients with epilepsy during both wakefulness and sleep states. The SEEG recordings will provide high-resolution intracranial electrophysiological data, while SPES will be employed to actively probe and quantify cortico-cortical connections. This combined approach will enable characterization of state-dependent neural network dynamics.

Study summary

This study aims to collect electrophysiological and clinical data from patients aged 14-65 with drug-resistant epilepsy who underwent SEEG. The collected data will be analyzed to investigate the functional connectivity during wakefulness and sleep states.

Eligibility

Sex

ALL

Min age

14 Years

Max age

65 Years

Healthy volunteers

Inclusion Criteria: * Drug-resistant focal epilepsy * Justified SEEG exploration in the context of presurgical assessment of epilepsy * Subjects will be a part of the epilepsy-monitoring unit for long-term SEEG recordings and analysis * Written non-opposition to study participation Exclusion Criteria: * Pregnant women (Contraindication to SEEG exploration) * Subjects that experience surgical complications during the implant procedure will be excluded from the study

Primary outcome measure(s)

SEEG recordings with SPES during daytime and sleeptime — 48 hours
Single-pulse electrical stimulation (SPES) serves as an effective dynamic marker for mapping functional brain connectivity. The stimulation parameters were set at 0.05 Hz, single biphasic pulses, 90 μs per phase, 4 mA.

Trial sites (1)

Facility	City	Region	Status
Xuanwu Hospital, Beijing	Beijing	Beijing Municipality	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06524479 on ClinicalTrials.gov ↗ ← All trials in China