Electroacupuncture Treatment of Behavioral and Psycological Symptoms in Patients With Alzheimer's Disease

Condition(s) studied

Investigational drug(s) / intervention(s)

Electroacupuncture treatment: Electroacupuncture treatment consists of conventional acupuncture and electrical stimulation. After acupuncture, the electrical stimulation is continuously stimulated.

Study summary

This study aims to establish a prospective case registration research platform for electroacupuncture in treating behavioral and psychological symptoms in patients with mild to moderate Alzheimer's disease, and to investigate the dose-effect relationship and cost-effectiveness of electroacupuncture for these symptoms.

Eligibility

Primary outcome measure(s)

• Neuropsychiatric Inventory (NPI) — NPI will be performed before treatment and every month after treatment for up to 24 months
  NPI is used to evaluate neuropsychiatric behavioral symptoms of dementia patients. The scale assesses the neuropsychiatric disorders of patients according to the caregiver's view of the patient's behavior and the corresponding distress felt by the patient. The scoring range of the patient evaluation scale is 0-144 points, and the scoring of the caregiver distress scale is 0-60 points, the lower the score is, the better the patient's condition is.
• Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC) — The ADCS-CGIC will be performed before treatment and every 2 month after treatment for up to 24 months
  ADCS-CGIC is a global rating of change developed to assess clinically significant change in symptoms over time in AD clinical trials. Clinicians rate patient symptoms on the ADCS-CGIC as: very much improved (1), much improved (2), minimally improved (3), no change (4), minimally worse (5), much worse (6), and very much worse (7) compared to baseline symptoms.

Trial sites (7)

More Guang'anmen Hospital of China Academy of Chinese Medical Sciences trials in China

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