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Clinical Trials in China / NCT06503263
Recruiting Phase 2

Zanubrutinib and Lenalidomide as Maintenance Therapy in DLBCL

NCT06503263 · tracked via the Priya Life Science China tracker
Sponsor
Navy General Hospital, Beijing
Phase
Phase 2
Started
2024-08-30
Last updated
2024-09-19

Condition(s) studied

Diffuse Large B-cell Lymphoma

Investigational drug(s) / intervention(s)

Zanubrutinib plus Lenalidomide as Maintenance Therapy →

Zanubrutinib plus Lenalidomide as Maintenance Therapy: Patients were treated by Zanubrutinib(160mg po bid d1-28) plus Lenalidomide(25mg po qd d1-14) as maintenance therapy until 2 years post chemotherpay

Study summary

The goal of this phase 2 trial is to test the safety and efficacy of zanubrutinib and lenalidomide as maintenance therapy in patients with DLBCL.

Eligibility

Sex
ALL
Min age
14 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Pathologically confirmed Diffuse Large B Cell Lymphoma according World Health Organization (WHO) classification; * Patient is ≥ 18 years of age at the time of signing the informed consent form (ICF). * Patient must understand and voluntarily sign an ICF prior to any study-specific assessments/procedures being conducted; * Patient is willing and able to adhere to the study visit schedule and other protocol requirements; * Patient has recieved complete remission and has completed planed courses of chemotherapy * Meet the following lab criteria: Absolute Neutrophil Count (ANC) ≥ 1,5 x 10\^9/L (≥ 1 x 10\^9/L if bone marrow (BM) involvement by lymphoma);Platelet ≥ 75 x 10\^9/L (≥ 50 x 10\^9/L if BM involvement by lymphoma); Hemoglobin ≥ 8 g/dL. Anticipated life expectancy at least 3 months Exclusion Criteria: * Active or uncontrolled infections requiring systemic treatment within 14 days before enrollment; * Any instability of systemic disease, including but not limited to severe cardiac, liver, kidney, or metabolic disease need therapy; * Pregnant or lactating women

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Navy General Hospital Beijing Beijing Municipality Recruiting

More Navy General Hospital, Beijing trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06503263 on ClinicalTrials.gov ↗ ← All trials in China