POASAC Study (Preoperative Anemia Severity and Classification Study)

NCT06499974 · tracked via the Priya Life Science China tracker

Sponsor

Peking Union Medical College Hospital

Phase

Observational

Started

2024-08-02

Last updated

2025-12-01

Condition(s) studied

Anemia

Study summary

The goal of this observational study focuses on the effect of different preoperative anemia status on perioperative complications in patients under moderate- to high-risk surgery. Different anemia types conclude iron-deficiency anemia(IDA), anemia of chronic disease/anemia of inflammation(ACD/AI), and combined anemia.The main question it aims to answer is whether there is a difference in the incidence of complication related to oxygen supply and demand imbalance in patients with IDA, ACD/AI or combined anemia.

Patients without preoperative anemia will be recruited as the control group for secondary outcome analysis, which is whether there is a difference in the incidence of complication related to oxygen supply and demand imbalance in patients with or without anemia.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Accepted

Inclusion Criteria: * age 18 years or older * scheduled for elective moderate- to high-risk surgery other than intracranial and cardiac surgery * predicted surgery time longer than 1 hour and hospital stay longer than 24 hours * understand and agree to participate Exclusion Criteria: * pregnant * live at areas higher than 2,500 meters above sea level * with hematological diseases other than anemia * with severe comorbidities that might interfere outcome assessment, like uremia, dementia, and so on * can't cooperate or communicate, or reject to sign informed consent form

Primary outcome measure(s)

postoperative complications related to oxygen supply and demand imbalance — before discharge or until seven days after surgery
The occurrence of any of the following complications is considered a positive outcome, which include myocardial injury after non cardiac surgery(MINS), acute kidney injury(AKI), neurological damage such as stroke and delayed neurocognitive recovery(DNR)

Trial sites (11)

Facility	City	Region	Status
Department of Anesthesiology, First Affiliated Hospital of Wannan Medical College	Wuhu	Anhui	Recruiting
Beijing Longfu Hospital (Beijing Geriatric Hospital of Integrated Traditional Chinese and Western Medicine)	Beijing	Beijing Municipality	Recruiting
Anesthesiology Department, Beijing NO.6 Hospital	Beijing	Beijing Municipality	Recruiting
BeiJing Hepingli Hospital	Beijing	Beijing Municipality	Recruiting
Beijing Puren Hospital	Beijing	Beijing Municipality	Recruiting
Peking Union Medical College Hospital	Beijing	Beijing Municipality	Recruiting
Science and Education Department, Zhangzhou Municipal Hospital of Fujian Province	Zhangzhou	Fujian	Recruiting
Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University	Zunyi	Guizhou	Recruiting
Department of Anesthesiology, Chifeng Municipal Hospital	Chifeng	Inner Mongolia	Recruiting
Department of Anesthesiology, The Affiliated Hospital of Inner Mongolia Medical University	Hohhot	Inner Mongolia	Recruiting
Inner Mongolia People's Hospital	Hohhot	Inner Mongolia	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06499974 on ClinicalTrials.gov ↗ ← All trials in China