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Clinical Trials in China / NCT06471257
Recruiting Phase 3

A Study to Investigate Efficacy and Safety of PT027 Compared With PT007 in Symptomatic Chinese Adults With Asthma

NCT06471257 · tracked via the Priya Life Science China tracker
Sponsor
AstraZeneca
Phase
Phase 3
Started
2024-06-17
Last updated
2026-09-21

Condition(s) studied

Asthma

Investigational drug(s) / intervention(s)

Budesonide/Albuterol metered dose inhaler, MDIAlbuterol sulfate metered dose inhaler, MDI

Budesonide/Albuterol metered dose inhaler, MDI: Combination Product (Drug + Device)

Albuterol sulfate metered dose inhaler, MDI: Combination Product (Drug + Device)

Study summary

An event-driven, Phase III study to evaluate the efficacy and safety of BDA MDI compared with AS MDI in reducing the risk of a severe asthma exacerbation in symptomatic Chinese adults with asthma.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: 1. Documented physician-diagnosed asthma for at least 12 months prior to Visit 1 2. Receiving 1 of the scheduled asthma maintenance therapies for 3 months with stable dosing for at least the last 4 weeks before Visit 1 3. Pre-bronchodilator FEV1 of ≥ 40% to \< 90% predicted normal value for adults. 4. Documented reversibility to albuterol 5. A documented history of at least one severe asthma exacerbation within 12 months before Visit 1 6. ACQ-7 score ≥ 1.5 assessed at Visit 1 7. ACQ-5 score ≥ 1.5 assessed at Visit 2 8. Receiving inhaled SABA as needed prior to Visit 1 for at least 3 months 9. Use of Sponsor-provided salbutamol sulfate inhalation aerosol as needed medication due to asthma symptoms on at least 3 days during the last week of the run-in period before Visit 2 10. Demonstrate acceptable MDI administration technique as assessed by the investigator; use of spacers is prohibited 11. Able to perform acceptable and reproducible PEF measurements as assessed by the investigator 12. BMI \< 40 kg/m2 13. Negative pregnancy test (urine at Visit 1) for female participants of childbearing potential 14. Women of childbearing potential must agree to prevent pregnancy 15. Compliance: must be willing to remain at the study site as required per protocol and complete all visit assessments Exclusion Criteria: 1. Chronic obstructive pulmonary disease or other significant lung disease 2. Oral/SCS use (any dose) within 6 weeks before Visit 1 3. Chronic use of OCS ≥ 3 weeks use in 3 months prior to Visit 1 4. Having received any marketed or investigational biologic within 3 months or 5 half-lives before Visit 1, whichever is longer, or any other prohibited medication 5. Current smokers, former smokers with \> 10 pack-years history, or former smokers who stopped smoking \< 6 months before Visit 1 6. Life-threatening asthma as defined as any history of significant asthma episode(s) requiring intubation associated with hypercapnia, respiratory arrest, hypoxic seizures, or asthma related syncopal episode(s) within last 5 years of Visit 1 7. Completed treatment for lower respiratory infection or asthma exacerbation within 6 weeks of Visit 1 8. Upper respiratory infection involving antibiotic treatment not resolved within 7 days before Visit 1 9. Clinically significant laboratory abnormalities 10. Historical or current evidence of a clinically significant disease 11. Cancer not in complete remission for at least 5 years before Visit 1 12. History of psychiatric disease, intellectual deficiency, poor motivation, or other conditions if their magnitude is limiting informed consent validity 13. Have a known or suspected hypersensitivity to albuterol/salbutamol, or budesonide and/or their excipients 14. Inability to abstain from protocol-defined prohibited medications during the study 15. Having received a live attenuated vaccination within 7 days of Visit 1 16. Currently pregnant or breastfeeding 17. Participants who experience \> 1 asthma exacerbation during the screening period

Primary outcome measure(s)

Trial sites (102)

FacilityCityRegionStatus
Research Site Baotou China Recruiting
Research Site Baotou China Recruiting
Research Site Beijing China Active Not Recruiting
Research Site Beijing China Recruiting
Research Site Beijing China Recruiting
Research Site Beijing China Recruiting
Research Site Changchun China Recruiting
Research Site Changchun China Recruiting
Research Site Changsha China Recruiting
Research Site Changsha China Recruiting
Research Site Chengdu China Recruiting
Research Site Chengdu China Recruiting
Research Site Chengdu China Recruiting
Research Site Chengdu China Recruiting
Research Site Chengdu China Recruiting
Research Site Chizhou China Recruiting
Research Site Chongqing China Recruiting
Research Site Chongqing China Recruiting
Research Site Chongqing China Completed
Research Site Dazhou China Recruiting
Research Site Deyang China Recruiting
Research Site Ganzhou China Recruiting
Research Site Guangyuan China Recruiting
Research Site Guangzhou China Active Not Recruiting
Research Site Guangzhou China Recruiting
Research Site Guangzhou China Completed
Research Site Guangzhou China Recruiting
Research Site Guangzhou China Recruiting
Research Site Guangzhou China Recruiting
Research Site Haikou China Active Not Recruiting
Research Site Hangzhou China Recruiting
Research Site Hangzhou China Withdrawn
Research Site Hefei China Recruiting
Research Site Hefei China Recruiting
Research Site Hefei China Recruiting
Research Site Heifei China Withdrawn
Research Site Hohhot China Recruiting
Research Site Hohhot China Recruiting
Research Site Huizhou China Recruiting
Research Site Huizhou China Recruiting

+ 62 more sites — see the full list on the official registry below.

More AstraZeneca trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06471257 on ClinicalTrials.gov ↗ ← All trials in China