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Clinical Trials in China / NCT06451861
Recruiting Phase 2

Randomized Study of ABC-14 Regimen Compared With "3+7" Standard Induction Therapy or AB-14 for ND AML

NCT06451861 · tracked via the Priya Life Science China tracker
Sponsor
Guangdong Provincial People's Hospital
Phase
Phase 2
Started
2024-08-21
Last updated
2025-11-17

Condition(s) studied

Acute Myeloid Leukemia

Investigational drug(s) / intervention(s)

ChidamideVenetoclaxazacitidineAnthracyclines or anthraquinonescytarabine

Chidamide: Induction Therapy

Venetoclax: Induction Therapy

azacitidine: Induction Therapy

Anthracyclines or anthraquinones: Induction Therapy

cytarabine: Induction Therapy

Study summary

To compare the efficacy and safty of ABC-14 regimen with the traditional "3+7" regimen or AB-14 regimen in the treatment of newly diagnosed acute myeloid leukaemia

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: 1. Diagnosed with AML (the diagnostic criteria refer to WHO2022 standard, non-APL), and have not received systemic anti-leukemia therapy (except hydroxyurea, low-dose cytarabine and other tumor reduction pretreatments); 2. Age ≥18 years old; 3. ECOG≤4; 4. The fertile woman agrees to use effective contraception during the treatment period and up to 3 months after the end of the treatment; Sign the informed consent form. Exclusion Criteria: 1. Known history of allergy to the investigational drug; 2. Resistance to azacytidine, azacitidine, Venetoclax; 3. Inability to take oral medication; 4. Combined with uncontrolled active infections (including bacterial, fungal or viral infections); 5. Combined with uncontrolled major organ dysfunction: cardiac insufficiency, decompensated liver insufficiency, moderate/severe renal insufficiency, etc.; 6. Participating in other clinical studies that affect the main purpose of this study; Patients deemed unsuitable for participation in this study.

Primary outcome measure(s)

Trial sites (13)

FacilityCityRegionStatus
Dongguan General Hosptial Dongguan Guangdong Recruiting
Foshan First People's Hospital Foshan Guangdong Recruiting
Guangdong Provincial People's Hospital Guangzhou Guangdong Recruiting
Sun Yat-sen University Cancer Center Guangzhou Guangdong Recruiting
The Fifth Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong Recruiting
The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou Guangdong Recruiting
The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong Recruiting
The First Affiliated Hospital of Jinan University Guangzhou Guangdong Recruiting
The Second Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong Recruiting
Shenzhen second people's Hospital Shenzhen Guangdong Recruiting
Affiliated Hospital of Guangdong Medical University Zhanjiang Guangdong Recruiting
Zhuhai General Hosptial Zhuhai Guangdong Recruiting
Hainan General Hosptial Haikou Hainan Recruiting

On this site

📄 Venclexta (venetoclax) drug profile →

More Guangdong Provincial People's Hospital trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06451861 on ClinicalTrials.gov ↗ ← All trials in China