Clinical Outcome in Patients With INPH

NCT06428734 · tracked via the Priya Life Science China tracker

Sponsor

Xuanwu Hospital, Beijing

Phase

Observational

Started

2024-05-15

Last updated

2024-05-24

Condition(s) studied

HydrocephalusIdiopathic Normal Pressure HydrocephalusCSFGlympathic SystemOmic

Investigational drug(s) / intervention(s)

hydrocephalus groupnormal group

hydrocephalus group: Diagnostic Test: high throughput sequencing and electromyography Whole Genome Sequencing, Whole Exome Sequencing, Transcriptomics, Proteomics, Metabolomics and imaging, such as DTIALPS

normal group: Whole Genome Sequencing, Whole Exome Sequencing, Transcriptomics, Proteomics, Metabolomics and imaging, such as DTIALPS

Study summary

The aim of this study is to determine the clinical spectrum and natural progression of idiopathic normal pressure hydrocephalus （iNPH ) and related disorders in a prospective single center study, identify digital, imaging and molecular biomarkers that can assist in diagnosis and therapy development and study the etiology and molecular mechanisms of these diseases.

Eligibility

Sex

ALL

Min age

18 Years

Max age

80 Years

Healthy volunteers

Accepted

Inclusion Criteria: * patients who was diagnosed as idiopathic normal pressure hydrocephalus Exclusion Criteria: * patient received surgical treatment or interventional treatment before patient is pregnant patient unable to complete follow-up patient with other types of hydrocephalus other nervous system diseases

Primary outcome measure(s)

DTIALPS — Change from Baseline at 6 months after VP shunt
Change of DTIALPS singal intensity in the resting state fMRI in iNPH patients compared with normal healthy group. Also, the responsive and non-responsive iNPH patients functional MRI were analzed.

Trial sites (1)

Facility	City	Region	Status
Fengzeng Jian	Beijing	Beijing Municipality	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06428734 on ClinicalTrials.gov ↗ ← All trials in China