The Third Affiliated Hospital of Guangzhou Medical University
Phase
Observational
Started
2024-01-01
Last updated
2024-05-20
Condition(s) studied
cfHPV DNA in Plasma of Cervical Cancer Patients
Investigational drug(s) / intervention(s)
Assess the risk of recurrence and the efficacy of medication
Assess the risk of recurrence and the efficacy of medication: Evaluation of recurrence risk and medication efficacy through liquid biopsy
Study summary
Assess the sensitivity, specificity, positive predictive value, and negative predictive value of dynamic monitoring of circulating tumor DNA (ctDNA) combined with circulating HPV DNA (cfHPV DNA) for early prediction of recurrence in cervical cancer post-surgery or post-treatment, and compare its advantages and disadvantages with existing diagnostic methods.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients with newly diagnosed HPV-positive cervical malignancy at stages I-IV who have not undergone surgery, radiation therapy, or chemotherapy.
* Patients must be older than 18 years of age.
* Cervical cancer patients who are eligible for surgery and/or chemoradiotherapy.
* Estimated life expectancy of more than three months.
* Understands the study protocol and voluntarily participates in the research by signing the informed consent form.
* Able to provide specimens and corresponding clinical information at each time point.
Exclusion Criteria:
* Patients who are participating in other clinical trials.
* Pregnant or breastfeeding women.
* Patients with severe mental illness.
* Patients who voluntarily withdraw.
* Patients unable to complete the study protocol.
Primary outcome measure(s)
sensitivity — 2 year true positive rate
Trial sites (1)
Facility
City
Region
Status
The Third Affiliated Hospital of Guangzhou Medical University
Guangzhou
Guangdong
Recruiting
More The Third Affiliated Hospital of Guangzhou Medical University trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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