Dementia is a syndrome characterized by progressive global cognitive impairment that impairs occupational, family, or social functioning. It detrimentally affects personal health and quality of life, imposing significant medical economy, social and psychological burden on the countries and the patients' family. The internationally renowned dementia cohort includes the DIAN that focused on genetics studies, the ADNI cohort featuring imaging and the FINGERS cohort focused on risk factor intervention, etc. Establishing standardized and shared longitudinal follow-up dementia cohorts and clinical database is an essential challenge for constructing dementia cohort in China. Moreover, there is a lack of large-scale prospective longitudinal follow-up cohorts within the Chinese population that cover subjective cognitive decline (SCD) to explore biomarkers with diagnostic and early warning value for different kinds of dementia and pre-dementia stages. The study will rely on the dementia cohort based on Chinese population to explore the biological phenotype characteristics of the pre-dementia stage and different dementia subtypes, and observe the dynamic change rules of the dementia cohort vertically, so as to foster early intervention and improve prognosis for individuals with dementia.
Eligibility
Sex
ALL
Min age
40 Years
Max age
90 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Male or female patients aged ≥40 and ≤90years;
* Chief complaint or others describe a cognitive decline;
* Ability to communicate in Chinese;
* The patients and their families were informed and signed the informed consent.
Exclusion Criteria:
* MMSE\<10;
* There are other neurological diseases that can cause brain dysfunction (such as depression, brain tumors, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, traumatic brain injury, normal intracranial pressure hydrocephalus, etc.);
* There are other systemic diseases that can cause cognitive impairment (such as hepatic insufficiency, renal insufficiency, Thyroid dysfunction, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.);
* Suffering from a disease that cannot cooperate with the completion of cognitive examination;
* There are contraindications to nuclear magnetic resonance;
* There is mental and neurodevelopmental delay;
* Refuse to draw blood;
* Refuse to sign the informed consent.
Primary outcome measure(s)
Rate of change in global cognition as measured by Clinical Dementia Rating (CDR). — 10 years Assess statistically significant difference in score between dementia-P and dementia-S using the neuropsychological scales CDR. CDR, a multidimensional scale for dementia severity, which scored 0-3, with higher scores indicating worse functioning.
Trial sites (1)
Facility
City
Region
Status
Capital Medical University Xuanwu Hospital
Beijing
China
Recruiting
More Cuibai Wei，Clinical Professor trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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