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Clinical Trials in China / NCT06402708
Recruiting Phase 3

Postoperative Adjuvant Chemotherapy for Thymic Cancer (FUSCC-Thymic 3)

NCT06402708 · tracked via the Priya Life Science China tracker
Sponsor
Fudan University
Phase
Phase 3
Started
2024-04-09
Last updated
2026-04-27

Condition(s) studied

Thymic Carcinoma

Investigational drug(s) / intervention(s)

ChemotherapyRadiotherapy

Chemotherapy: paclitaxel 60mg/m2, ivgtt; cisplatin 30mg/m2, ivgtt; 5-FU 500mg/m2, ivgtt and 500mg/m2, civ 24h; calcium folinate 200mg; q3w.

Radiotherapy: IMRT, 50Gy/25f

Study summary

The goal of this clinical trial is to learn the role of adjuvant chemotherapy for patients with thymic carcinoma and completed resection. The main questions it aims to answer are:

1. Does adjuvant chemotherapy decrease disease progression?
2. Does medium dose of three drugs (paclitaxel, cisplatin, 5-FU) well tolerance?

Researchers will compare chemoradiotherapy to radiotherapy to see whether chemoradiotherapy could decrease disease progression or not.

Participants will:

1. Take radiotherapy (50Gy/25f) with or without 4 cycles of chemotherapy (TPF).
2. Follow up every 3 months in the first two year, and then every 6 months.

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: 1. Voluntarily participate and sign an informed consent form in writing; 2. Age range from 18 to 75 years old, regardless of gender; 3. Within 3 months after the surgery is completed; 4. Histologically diagnosed with thymic cancer; 5. Complete resection based on surgical records, pathological reports, and postoperative imaging; 6. Masaoka stage: I-III 7. No severe hematopoietic function, heart, lung, liver, kidney dysfunction, or immune deficiency; 8. White blood cells ≥ 3 × 109/L; Neutrophils ≥ 1.5 × 109/L; Hemoglobin ≥ 10 g/dL; Platelets ≥ 100 × 109/L; Total bilirubin ≤ 1.5 times the upper limit of normal value; AST (SGOT)/ALT (SGPT) ≤ 2.5 times the upper limit of normal value; Creatinine ≤ 1.5 times the upper limit of normal value; Exclusion Criteria: 1. Having a second primary tumor (excluding cured non malignant melanoma of the skin, papillary thyroid carcinoma, stage I seminomatoma, cervical carcinoma in situ, or other curable tumors that have been tumor free for more than 3 years after treatment); 2. Symptomatic coronary heart disease, left heart failure, uncontrollable seizures, or loss of self-awareness due to mental illness; 3. Pregnancy and lactation period; 4. Patients with drug addiction, chronic alcoholism and AIDS; 5. Researchers believe that participants are not suitable for this experiment.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Fudan University Shanghai Cancer Center Shanghai Shanghai Municipality Recruiting

More Fudan University trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06402708 on ClinicalTrials.gov ↗ ← All trials in China