Deep Brain Stimulation SurgeryElectrophysiologyGeneral AnesthesiaConsciousness, Loss of
Investigational drug(s) / intervention(s)
No interventions
No interventions: No interventions were given to patients except for the deep brain stimulation surgery they originally planned to take
Study summary
The correlations of deep brain nuclei firing and cerebral cortex activity during recovery from general anesthesia is unclear. In this study, the local field potential (LFP) from the deep brain nuclei and the scalp electroencephalogram (EEG) of the frontal cortex were recorded from patients undergoing deep brain stimulation (DBS) surgery during the recovery from general anesthesia, in order to explore the changes and relevance of deep brain nuclei firing and cortex activity during the recovery of consciousness from general anesthesia .
Eligibility
Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria:
* 18-75 years old
* ASA (American Society of Anesthesiologists) classification I-III
* Those who meet the indications for DBS surgery
* Right-handed with normal listening and speaking abilities
* The patient signs the informed consent form and cooperates with the researchers
Exclusion Criteria:
* Patients with cognitive impairment \[Montreal Cognitive Assessment (MoCA) score less than 26 points\];
* Patients with severe depression \[Beck Depression Inventory (BDI-II) score greater than or equal to 25 points\];
* Patients with important organs dysfunction, such as heart, lungs, liver, and kidneys; or patients with unstable vital signs;
* Patients who are expected to enter the ICU after surgery;
* Patients who are alcoholic, alcohol dependent or drug dependent;
* Patients who have received general anesthesia one month before surgery, patients who are known to be allergic to general anesthetics;
* The DBS surgery exceeds 4 hours;
* Patients who are pregnant.
Primary outcome measure(s)
Number of Participants With Changes in the Local Field Potential from the Deep Brain Nuclei and the Scalp Electroencephalogram of the Frontal Cortex. — 2 hours. Number of participants with changes in the local field potential from the deep brain nuclei and the scalp electroencephalogram of the frontal cortex during recovery of consciousness from general anesthesia. The recovery of consciousness is defined as the patient can follow the experimenter's verbal command to open mouth and extubate the endotracheal tube.
Trial sites (1)
Facility
City
Region
Status
Ruijin Hospital Shanghai Jiaotong University School of Medicine
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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