The idiopathic generalized epilepsies (IGEs) have historically included the syndromes childhood absence epilepsy (CAE), juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), and epilepsy with generalized tonic-clonic seizures alone (GTCA). Recognition of the IGEs is important for clinical care, as it informs diagnosis, prevents unnecessary investigation, allows optimal selection of anti-seizure medications (ASMs), and provides prognostic guidance.
According to the new ILAE definition in 2022, the study aims to describe the clinical features, electroencephalographic, imaging findings and long-term prognosis.
Eligibility
Sex
ALL
Min age
4 Years
Max age
40 Years
Healthy volunteers
No
Inclusion Criteria:
* Patients are consecutively and prospectively enrolled from epilepsy center, with newly diagnosed epilepsy or established epilepsy.
* Patients have a diagnosis of idiopathic generalized epilepsy (IGE), according to the 2022 diagnostic criteria.
* Comprehensive clinical information is collected, and 24 hour video-electroencephalography is performed.
* Sign the informed consent forms.
Exclusion Criteria:
* Other epilepsy syndromes are considered during follow-up, such as genetic generalized epilepsy.
* Lost to follow-up
Primary outcome measure(s)
The proportion of drug-resistent epilepsy — through study completion, an average of 1 year We defined drug-resistant cases as those patients who have failed two or more trials of broad-spectrum ASMs or those otherwise indicated in IGE syndromes
The proportion of seizure freedom — through study completion, an average of 1 year We defined seizure freedom according to the International League Against Epilepsy (ILAE) definition
Trial sites (1)
Facility
City
Region
Status
2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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