tDCS stimulation: In the real-stimulation group, Treatment was for 20 min, repeated twice in a day, then again over the next few days. The maximum number of stimuli required to terminate the status epilepticus should not exceed 10. In the sham-stimulation group, The duration and frequency of tDCS are the same as those in the treatment group, but the tDCS device is not active during the 20 minutes of sham-stimulation
TDCS sham-stimulation: TDCS sham-stimulation
Study summary
The purpose of the study is to assess the efficacy and safety of targeting tDCS stimulation for treatment of Refractory status epilepticus
Eligibility
Sex
ALL
Min age
14 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria:
* Age between 14 and 80 year-old with Gender unlimited,
* Suitable for EEG monitoring;
* Clinical diagnosis of Refractory status epilepticus (status epilepticus that cannot be controlled by two types of antiepileptic drugs and at least one anesthetic);
* Informed consent to participate in this study was obtained from the participants or their surrogates
Exclusion Criteria:
* Unstable vital signs (systolic blood pressure\<90mmHg, heart rate\<60 beats/min, pulse oxygen saturation\<90%);
* Having severe skull injury/defect or medical equipment implanted in the head;
* Pregnancy;
* With any implantable electronic instrument (including pacemakers, vagus nerve stimulators) or metal implanted devices.
Primary outcome measure(s)
Number of participants with status epilepticus termination between tDCS treatment group and tDCS sham--stimulation group as assessed by Salzburg Consensus Criteria for Non-Convulsive Status Epilepticus — through study completion, an average of 1 year Outcomes will be assessed by clinical observation and EEG evaluation before 10 times of tDCS stimulation between both groups
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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