The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Phase
Not applicable
Started
2024-06-01
Last updated
2025-02-17
Condition(s) studied
Neuromuscular Blockade
Investigational drug(s) / intervention(s)
SUGAMMADEX SODIUM 100 Mg in 1 mLNeostigmine
SUGAMMADEX SODIUM 100 Mg in 1 mL: The dose of Sugammadex Sodium 100 Mg in 1 mL is 2mg/kg
Neostigmine: Neostigmine is 50 μg/kg
Study summary
This study aims to compare the use of sugammadex (domestic) and neostigmine for antagonism after thoracic surgery, and observe the effect of sugammadex (domestic) on neuromuscular blockade antagonism after thoracic surgery, in order to provide a basis for optimizing the use of muscle relaxants and their antagonists during anesthesia.
Eligibility
Sex
ALL
Min age
19 Years
Max age
75 Years
Healthy volunteers
Accepted
Inclusion Criteria:
1. Patients who undergo elective lung surgery under general anesthesia and require endotracheal intubation;
2. Age\>18 years old, gender not limited;
3. American Society of Anesthesiologists ASA Level I-III;
4. Use rocuronium bromide for neuromuscular blockade;
5. The patient voluntarily participated in the trial.
Exclusion Criteria:
1. The patient explicitly refused to participate in this trial;
2. Family history of malignant hyperthermia, patients with allergies to sodium sulbactam, neostigmine ingredients and their excipients, and patients with allergies to drugs used during general anesthesia;
3. Patients with tracheal malformations or suspected difficult airways, coagulation dysfunction, severe liver and kidney dysfunction, and severe lung disease;
4. Patients who are not extubated and sent to the ward or ICU after surgery;
5. The researchers believe that patients with any other unfavorable factors to participate in this trial.
Primary outcome measure(s)
Muscle relaxation recovery time — Usually from half an hour to several hours(depending on the length of the procedure) The time from using antagonists to TOFr recovery to 0.9
Trial sites (1)
Facility
City
Region
Status
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Yiwu
Zhejiang
Recruiting
More The Fourth Affiliated Hospital of Zhejiang University School of Medicine trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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