A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia

NCT06334549 · tracked via the Priya Life Science China tracker

Sponsor

Dalian Municipal Central Hospital

Phase

Phase 4

Started

2024-03-05

Last updated

2024-11-06

Condition(s) studied

Hypotension Drug-Induced

Investigational drug(s) / intervention(s)

Ephedrine-PPhenylephrine-PNorepinephrine-PEphedrine-SPhenylephrine-SNorepinephrine-S

Ephedrine-P: after induction of anesthesia, use total intravenous anesthesia maintained with propofol

Phenylephrine-P: after induction of anesthesia, use total intravenous anesthesia maintained with propofol

Norepinephrine-P: after induction of anesthesia, use total intravenous anesthesia maintained with propofol

Ephedrine-S: after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane

Phenylephrine-S: after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane

Norepinephrine-S: after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane

Study summary

The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.

Eligibility

Sex

ALL

Min age

18 Years

Max age

80 Years

Healthy volunteers

Inclusion Criteria: * ASA I-III, age 18-80 years * Elective abdominal surgery * Signed informed consent Exclusion Criteria: * ASA≥IV * Preoperative unstable blood hemodynamics * Allergy to ephedrine, phenylephrine or norepinephrine * Decrease in MAP \<20% * Severe cardiovascular disorder

Primary outcome measure(s)

Continual changes in Cerebral Oxygen Saturation — 10 minutes after entering the operating room; when 20% decrease in baseline MAP after both induction of anesthesia and intubation; when MAP rising to the highest point after administration of vasopressors
This outcome is measured by near-infrared spectroscopy

Trial sites (1)

Facility	City	Region	Status
Dalian Municipal Central Hospital	Dalian	Liaoning	Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06334549 on ClinicalTrials.gov ↗ ← All trials in China