Prenatal Exposure to Emerging Contaminants and Children's Atopic Dermatitis

NCT06316609 · tracked via the Priya Life Science China tracker

Sponsor

Children's Hospital of Fudan University

Phase

Observational

Started

2016-06

Last updated

2026-05-15

Condition(s) studied

Atopic Dermatitis

Investigational drug(s) / intervention(s)

Gestational Exposure to Emerging Contaminants (ECs)

Gestational Exposure to Emerging Contaminants (ECs): Levels of Emerging Contaminants (ECs), such as Per- and Polyfluoroalkyl Substances (PFASs), Organophosphate Flame Retardants (OPFRs), and Microplastics, are assessed in maternal blood and umbilical cord blood during gestation.

Study summary

This prospective cohort study aims to investigate the association between prenatal blood levels of Emerging Contaminants and the five-year incidence of atopic dermatitis (AD) in offspring.

Eligibility

Sex

ALL

Min age

—

Max age

—

Healthy volunteers

Inclusion Criteria: * Mother plans to proceed prenatal care and delivery in Minhang Maternal and Children Health Care Hospital * 12-14 weeks of singleton pregnancy, non-stillborn or miscarrying, offspring without familial hereditary skin diseases * Offspring plans to stay in Shanghai until 5 years and proceed follow-up at the Dermatology Department of Children's Hospital affiliated with Fudan University * signed informed consent. Exclusion Criteria: * Multiple pregnancies * perinatal death * a fetus with congenital skin or appendages disorders

Primary outcome measure(s)

atopic dermatitis: Infant atopic dermatitis incidence — at 1 year old
Disease diagnosis according to the criteria of Williams. Skin status was examined via onsite interview by pediatric dermatologists. Parents consulted or visited a dermatologist once their baby developed any skin symptoms.

Trial sites (1)

Facility	City	Region	Status
Children Hospital of Fudan University	Shanghai	Shanghai Municipality

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Other trials for the same condition

A Clinical Study of AK120 in Adolescents With Moderate-to-severe Atopic Dermatitis (AD) Starting soon

A Proof-of-Concept Study of IBI3002 in Patients With Moderate to Severe Atopic Dermatitis Recruiting

A Long-term Study of the Medicine Called Abrocitinib in Children Aged 2 Years and Older With Moderate to Severe Eczema Recruiting

Study of CM310 in Adolescent Subjects With Atopic Dermatis Active, not recruiting

ICP-332 in Subjects With Moderate to Severe Atopic Dermatitis Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06316609 on ClinicalTrials.gov ↗ ← All trials in China