Study of CM310 in Patients With Uncontrolled Seasonal Allergic Rhinitis

NCT06300203 · tracked via the Priya Life Science China tracker

Sponsor

Beijing Tongren Hospital

Phase

Phase 2

Started

2024-03-18

Last updated

2025-09-25

Condition(s) studied

Seasonal Allergic Rhinitis

Investigational drug(s) / intervention(s)

Interleukin-4 receptor respondersPlacebo

Interleukin-4 receptor responders: Interleukin-4 receptor was injected subcutaneously.

Placebo: Placebo was injected subcutaneously.

Study summary

Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of the nasal mucosa mainly mediated by immunoglobulin E after exposure to allergens in atopic individuals. The typical symptoms of AR are paroxysmal sneezing, watery rhinorrhea, itching, and nasal congestion, which may be accompanied by ocular symptoms, including eye itching, tearing, redness, and burning sensation, which are more common in patients with hay fever allergies. Bronchial asthma is associated with bronchial asthma in 40% of patients with AR, suggesting a comorbid feature of allergic disease.

Eligibility

Sex

ALL

Min age

18 Years

Max age

65 Years

Healthy volunteers

Inclusion Criteria: * Voluntarily sign the informed consent form. Exclusion Criteria: * Have any condition that are not suitable for participating in this study.

Primary outcome measure(s)

Average change from baseline in daily retrospective total nasal symptom score (rTNSS) at week 2. — up to Week 2
Average change from baseline in daily retrospective total nasal symptom score (rTNSS) during treatment period. The Total Nasal Symptom Score (TNSS) is the sum of the four symptom scores of runny nose, nasal congestion, nasal itching, and sneezing, with each symptom scoring from 0 to 3.

Trial sites (1)

Facility	City	Region	Status
Beijing Tongren Hospital, Capital Medical University	Beijing	Beijing Municipality	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06300203 on ClinicalTrials.gov ↗ ← All trials in China