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Recruiting Phase 2

A Study of RAY1225 in Participants With Obesity

NCT06254261 · tracked via the Priya Life Science China tracker
Phase
Phase 2
Started
2024-02-21
Last updated
2025-03-19

Condition(s) studied

Obesity

Investigational drug(s) / intervention(s)

RAY1225 →Placebo

RAY1225: Administered SC

Placebo: Placebo

Study summary

The main purpose of this study is to learn more about the Tolerability of RAY1225 in participants with Obesity. The study will also explore the efficacy of RAY1225. The study will last about six months for each participant.

Eligibility

Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
No
Inclusion Criteria: 1. Have a body mass index (BMI) of ≥28 kilogram per square meter (kg/m²) or ≥24 kg/m² and previously diagnosed with at least one of the following weight related comorbidities: hypertension, dyslipidemia, obstructive sleep apnea, fatty liver disease,or HbA1c ≥5.7% and \< 6.5%; 2. Participants (including partners) must use reliable methods of contraception during the study and until 6 months following the last dose of investigational product. Exclusion Criteria: 1. Obesity induced by other endocrinologic disorders or monogenetic or syndromic forms of obesity 2. with a history of diabetes or hypoglycemia; 3. Have a family or personal history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia (MEN) Syndrome type 2 or with thyroid nodules of unknown etiology found at screening and considered clinically significant by the investigator. 4. Have a prior or planned surgical treatment for obesity (excluding liposuction or abdominoplasty if performed \>1 year prior to screening) 5. allergic constitution; 6. not suitable for subcutaneous injection.

Primary outcome measure(s)

  • Change From Baseline in Body Weight — Baseline,Week26
    Percent Change from Baseline in Body Weight

Trial sites (1)

FacilityCityRegionStatus
Peking University People's Hospital Beijingcun Hebei Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06254261 on ClinicalTrials.gov ↗ ← All trials in China