Cohort Study of Clinical and Neuroimaging Characteristics for BPPV Patients in China

Condition(s) studied

Investigational drug(s) / intervention(s)

Simultaneous cortico-spinal magnetic resonance imaging, Serum: Simultaneous cortico-spinal magnetic resonance imaging data were collected in a strong magnetic field and collected the serum of participants.

Study summary

The main objective is to analyze the abnormality of physical condition, mental health and blood examination of the patients with benign paroxysmal positional vertigo (BPPV). Besides, the investigators aim to establish a database of BPPV based on multimodal magnetic resonance imaging data in the brain to identify high-risk patients with residual dizziness (RD) and systematically establish the comprehensive assessment system for the precise diagnosis, treatment and recovery of RD, optimize the tactics of BPPV management in China.

Eligibility

Primary outcome measure(s)

• Differences between patients with BPPV and control group in brain structure — baseline and 1 and 6 months
  The changes of brain volume (mm3) are evaluated by structural MRI
• Differences between two groups in brain function — baseline and 1 and 6 months
  The changes of brain functional connectivity intensity are evaluated by functional MRI
• Changes on vertigo symptoms — baseline and 1 and 6 months
  Vertigo is assessed with the Dizziness Handicap Inventory (DHI Scale)
• Changes on vertigo symptoms — baseline and 1 and 6 months
  Vertigo is also assessed with the Activities-specific Balance Confidence Scale (ABC Scale)
• Changes on vertigo symptoms — baseline and 1 and 6 months
  Vertigo is also assessed with the Visual Vertigo Analogue Scale (VVAS)
• Difference in blood markers between the two groups — baseline and 1 and 6 months
  All subjects underwent fasting vein blood collection of about 5 ml at about 8 a.m. Blood indices related to BPPV and related clinical symptoms were screened, the inflammatory index is interleukin-6（IL-6）
• Difference in blood markers between the two groups — baseline and 1 and 6 months
  Immunology-related index in the blood sample is superoxide dismutase (SOD)
• Difference in blood markers between the two groups — baseline and 1 and 6 months
  Inflammatory index in the blood sample is neutrophils/lymphocytes

Trial sites (1)

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