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Clinical Trials in China / NCT06215326
Recruiting Not applicable

Short-term Effects of Preoperative Exercise in Moderate-to-high Perioperative Risk Lung Cancer Patients

NCT06215326 · tracked via the Priya Life Science China tracker
Sponsor
Guangdong Provincial People's Hospital
Phase
Not applicable
Started
2024-01-23
Last updated
2026-08-03

Condition(s) studied

Lung Cancer

Investigational drug(s) / intervention(s)

moderate-intensity continuous traininghigh-intensity interval training

moderate-intensity continuous training: Each MICT session consists of 30 minutes of cycling. Workload will be gradually titrated from 50% to 60% peak WR throughout training to sustain a target RPE of 12-14 on the Borg 6-20 scale.

high-intensity interval training: Each HIIT session consists of15 cycles, includes a 60-second high-intensity interval at 80-95% peak WR (target RPE 15-17) followed by a 60-second active recovery phase at 25% peak WR.

Study summary

The goal of this clinical trail is to compare the effects of preoperative exercise training of different intensities on short-term cardiorespiratory function and postoperative outcomes in patients scheduled for lung resections.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: 1. Age\>18 years. 2. Suspected or confirmed primary lung cancer with scheduled surgical treatment. 3. Moderate-to-high perioperative risk, defined as FEV1\<60% of predicted value (wedge) or ppo FEV1\<60% of predicted value (lobectomy/segmentectomy) or VO2peak\<20 ml/kg/ min. 4. Sign informed consent and accept to comply with the requirements of the study protocol. 5. Completion of a baseline Complete cardiopulmonary exercise testing (CPET). Exclusion Criteria: 1. Concurrent or previous history of other malignant tumors. 2. Life expectancy less than 1 year. 3. Dementia; infirmity; or inability to participate in sports (musculoskeletal limitations, namely, injuries, frailty, and weakness). 4. Inability to maintain exercise training. 5. Irregular vital signs (heart rate: \< 40 or \> 120 bpm at rest; blood pressure: systolic blood pressure \> 200 mm Hg or diastolic pressure \> 110 mm Hg; T: ≥ 38.5 or ≤ 36◦C; SpO2 ≤ 90%). 6. Currently enrolling in any other clinical trials. 7. Patient refusal.

Primary outcome measure(s)

  • cardiopulmonary fitness — baseline，2 weeks
    The post-training change in cardiorespiratory fitness will be measured by the VO2peak in ml/kg/min.VO2peak will be evaluated by a cardiopulmonary exercise test.

Trial sites (1)

FacilityCityRegionStatus
Guangdong Provincial People's Hospital Guangzhou Guangdong Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06215326 on ClinicalTrials.gov ↗ ← All trials in China