Clinical Value of DWI-ADC Matching in the Short-term Prognosis of Wilson's Disease

Condition(s) studied

Study summary

In earlier studies, it was found that patients of Wilson disease with new diagnosed who only has neurological symptoms often had DWI hyper-intensity in brain MRI, which was more common in putamen and midbrain, indicating that the disease was in the acute stage. However, many patients had ADC hyper-intensity or hypo-intensity at the same time, and the two different signals represented different disease processes from an imaging perspective. The former indicating T2 penetration effect, and the latter represents diffusion limitation, which indicating the presence of local inflammation, edema, etc. Whether the signal changes of these two different matching modes have guiding significance for the early de-copper treatment for WD, one is the core point of our study. We hope to exploring the predictive value about DWI-ACD signal matching for symptoms changes in the earlier time of de-copper treatment through this study.

Eligibility

Primary outcome measure(s)

• UWDRS scales — Before and 4 weeks after treatment
  It is used to evaluate the changes of patients' nervous system symptoms
• 24h urine copper — Before and 4 weeks after treatment
  used to evaluate the changes of patients' nervous system symptoms

Trial sites (1)