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Clinical Trials in China / NCT06162988
Starting soon Not applicable

PET Imaging of 68Ga-NOTA-H006 in Malignancy

NCT06162988 · tracked via the Priya Life Science China tracker
Sponsor
YiHui Guan
Phase
Not applicable
Started
2023-12
Last updated
2023-12-08

Condition(s) studied

Tumor, Solid

Investigational drug(s) / intervention(s)

68Ga-NOTA-H006 is injected intravenously with a dose of 1.8 MBq[0.05MCi]/kg.

68Ga-NOTA-H006 is injected intravenously with a dose of 1.8 MBq[0.05MCi]/kg.: 68Ga-NOTA-H006:PET imaging; 18F-FDG:PET imaging

Study summary

5T4, also known as trophoblast glycoprotein, is an oncofoetal antigen expressing in fetal development and cancer but rarely in adult. The high expression of 5T4 in malignancy was found be associated with poor clinical outcomes in ovarian, gastric and colorectal cancers. Several antibody drug conjugates are currently under development for cancer therapy in preclinic and clinic stages.

Previously, investigators engineered a 5T4-specific biomolecule with nanomolar binding affinity. Radiolabeling with gallium-68 resulted in 68Ga-NOTA-H006 which showed 5T4 expression in a variety of xenograft models. Thus, the aims of current study are to evaluate the distribution and dosimetry of this novel tracer, and to explore the diagnostic values of 68Ga-NOTA-H006 in malignant tumors.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: * Pancreatic cancer clinical trial study subjects must meet all of the following criteria: 1. Age between 18 and 65 years old. 2. Pancreatic occupancy is found on imaging and combined with clinical judgment as a patient with pancreatic cancer. 3. Written informed consent signed by the subject or his/her legal guardian or caregiver. 4. Willingness and ability to cooperate with all programs of the study. Lung cancer clinical trial study subjects must meet all of the following criteria: 1. Be between the ages of 18 and 65 years old. 2. Patients with CT findings of suspicious space on the lungs with a diameter of more than 1cm who have not undergone surgery. 3. Written informed consent must be signed by the subject or his/her legal guardian or caregiver. 4. Willingness and ability to cooperate with all programs of the study. Bowel cancer clinical trial study subjects must meet all of the following criteria: 1. Be between the ages of 18 and 65. 2. Have a clear histologic or pathologic diagnosis of colorectal cancer. 3. Written informed consent signed by the subject or legal guardian or caregiver. 4. Willingness and ability to cooperate with all programs of this study. Exclusion Criteria: 1. Severe hepatic or renal insufficiency; 2. Targeted therapy prior to radiotherapy or PET/CT scan. 5T4 expression in existing lesions assessed by immunohistochemistry using antibody clones. 3. History of serious surgery in the last month. 4. Those who have participated in other clinical trials during the same period.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Huashan Hospital Shanghai China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06162988 on ClinicalTrials.gov ↗ ← All trials in China