Post-transplant PT/FLU+CY Promotes Unrelated Cord Blood Engraftment in Haplo-cord Setting in Childhood Leukemia

NCT06155188 · tracked via the Priya Life Science China tracker

Sponsor

Nanfang Hospital, Southern Medical University

Phase

Not applicable

Started

2019-09-29

Last updated

2023-12-04

Condition(s) studied

LeukemiaStem Cell TransplantCord Blood

Investigational drug(s) / intervention(s)

applying of FLU+CY post-HSCT

applying of FLU+CY post-HSCT: The conditioning regimen (PT-Cy/Flu group) consisted of fludarabine (40mg/m2, d-5 to d-3 and d+3, d+4), busulfan (100mg/m2, d-6 to d-3), haplo-PBSC (d0), PTCy (50mg/kg, d+3, d+4) and UCB (d+6).

Study summary

To determine if the novel regimen of PT/FLU+CY promotes cord blood engraftment in children's leukemia HSCT cohort

Eligibility

Sex

ALL

Min age

1 Month

Max age

18 Years

Healthy volunteers

Inclusion Criteria: * children acute leukemia Exclusion Criteria: * MODS

Primary outcome measure(s)

rate of UCB engraftment — initiate STR detection from day+15 thereafter weekly up to 1 year post-HSCT
evaluate the regimen if it promotes UCB engraftment
rate of leukemia free survival — 3 years post-HSCT
determine the leukemia status post-HSCT
rate of overall survival — 3 years post-HSCT
determine the overall survival status post-HSCT

Trial sites (1)

Facility	City	Region	Status
Nanfang Hospital	Guangzhou	Guangdong	Recruiting

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Other trials for the same condition

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A Study Comparing Haploidentical Hematopoietic Stem Cell Transplantations (HSCTs) From Young Non-first-degree and Older First-degree Donors in Hematological Malignancies Active, not recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06155188 on ClinicalTrials.gov ↗ ← All trials in China