Rest Gated Myocardial Perfusion Imaging in Heart Failure
Investigational drug(s) / intervention(s)
Standard medical care for heart failure
Standard medical care for heart failure: Standard treatment and care for heart failure patients from the heart failure center of Sichuan Provincial People's Hospital.
Study summary
The clinical feasibility of 18F-FMBG cardiac PET imaging will be observed in sympathetic nervous system activity in patients with heart failure, predicted cardiac events, guided ICD implantation, and evaluated therapy efficiency.
Eligibility
Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* 1\. Clinically confirmed patient with chronic heart failure, LVEF ≤ 40%, cardiac function NYHA 2-3 grade, survival period greater than 1 year, evaluated by the Heart Failure Center of Sichuan Provincial People's Hospital.
* 2\. Chronic heart failure patients were evaluated by the Cardiology Department of Sichuan Provincial People's Hospital 5-10 days before ICD implantation.
* 3\. All patients above have signed an informed consent form.
Exclusion Criteria:
* 1\. Heart failure, heart function NYHA levels ⅠOR Ⅳ.
* 2\. The patient has already implanted ICD or CRT.
* 3\. Heart transplant patients.
* 4\. Patients with malignant tumors.
* 5\. Heart valve disease.
* 6\. Myocardial infarction occurred within the past three months.
* 7\. The patient has contraindications for ICD implantation surgery.
* 8\. The patient does not cooperate or is unwilling to conduct the study.
Primary outcome measure(s)
observe the 18F-MFBG distribution of the myocardium in heart failure patients — 1 year 18F-MFBG PET cardiac sympathetic nerve imaging was performed after injection of 30 minutes and 3 hours. The imaging agent distribution of left ventricular walls was observed at three axis positions (short axis, horizontal long axis, and vertical long axis). Target heart maps (17 segments) were obtained using Cedars QPS software to obtain radiation distribution counts (SMSe, SMSlate).
Trial sites (1)
Facility
City
Region
Status
Zhi Ling Ding
Chengdu
Sichuan
More Sichuan Provincial People's Hospital trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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