ALI/ARDS Clinical Sub-phenotyping Study

Condition(s) studied

Investigational drug(s) / intervention(s)

Collect peripheral blood and bronchoalveolar lavage fluid: Peripheral venous blood will be collected and stored from the study participants at a total of five time points: Day 0, Day 1, Day 2, Day 3 after admission to the ICU, and the day of ICU discharge/death. The collection will be conducted after assessing the patients' eligibility for ARDS diagnosis. Each time point will involve the collection of one tube of peripheral venous blood, totaling 5 mL per sample. Within 24 hours after patients' admission to the ICU and meeting the assessment criteria for ARDS diagnosis, bronchoalveolar lavage fluid (BALF) will be collected and retained, totaling 10 mL.

Study summary

1. Construct a structured clinical data and biosample information platform for Chinese patients with acute lung injury/ acute respiratory distress syndrome.
2. By deciphering the heterogeneity of patients with acute lung injury/ acute respiratory distress syndrome, achieve clinical, longitudinal physiological, and biological sub-phenotyping to guide individualized precision treatment and improve prognosis.

Eligibility

Primary outcome measure(s)

• ICU mortality — up to 12 weeks
  In ICU mortality
• hospital mortality — up to 24 weeks
  In hospital mortality

Trial sites (1)

More China-Japan Friendship Hospital trials in China