Efficacy and Safety of Urinary Kallidinogenase in the Treatment of Acute Ischemic Stroke Combined With Type 2 Diabetes Mellitus

Inclusion Criteria: * Age ≥18 years old and ≤80 years old; * Patients with acute ischemic stroke diagnosed with complete anterior circulation infarction (TACI) and partial anterior circulation infarction (PACI) according to Oxfordshire Community Stroke Project classification (OCSP), see Appendix 6; * Refer to the Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes (2020 edition), have been diagnosed with type 2 diabetes (need to have a medical history to confirm), see Appendix 7; * The time from the occurrence of the stroke to the time of admission is less than 48h. If the exact time of onset is unknown, the time of onset of the patient is defined as "the time that finally seems normal"; * First-ever ischemic stroke or have history of ischemic stroke but mRS≤1 before onset; * 6≤NIHSS≤20; * Have provided signed written informed consent from the patient or the patient's legal representative Exclusion Criteria: * Acute intracranial hemorrhagic diseases confirmed by imaging: parenchymal hemorrhage, epidural hematoma, subdural hematoma, ventricle hemorrhage, subarachnoid hemorrhage, etc. * Patients who are ready to undergo or have undergone intravascular interventional therapy after the onset of the disease; * Patients who are ready to undergo or have undergone intravenous thrombolytic therapy after the onset of the disease; * Severe disturbance of consciousness: NIHSS 1a consciousness level score ≥2; * Patients with fracture, claudication and other factors affecting functional outcome score upon admission; * After the onset of the disease, Edaravone injection, Edaravone and Dexborneol concentrated solution for injection, Butylphthalide and sodium chloride injection or Butylphthalide soft capsules have been used; * Chinese patent medicine injection for improving cerebral blood circulation has been applied after the onset of this disease (see 8.4.2 for details); * Patients with hypotension (blood pressure less than 90/60mmHg) upon admission; * Have a history of severe food or drug allergy, or have been allergic to or intolerant of Eurecline injection; * Eurecline for injection has used angiotensin-converting enzyme inhibitor (ACEI) drugs before taking the drug and has not exceeded 5 half-lives (according to the specific drug instructions); * Patients who are pregnant or breastfeeding and who plan to become pregnant within 90 days; * Renal failure or severe renal impairment at the time of screening (creatinine clearance \< 30ml/min); * Liver function impairment: alanine aminotransferase (ALT), aspartate aminotransferase (AST) \> 2.5 times the upper limit of normal, or other known serious liver diseases such as active infection of acute and chronic hepatitis, cirrhosis, etc.; * Patients with heart failure (NYHA class III or IV), unstable angina pectoris, acute myocardial infarction, severe arrhythmia, and degree II and III cardiac conduction obstruction within 6 months prior to randomization; * Those who meet the heavy drinking standard in the three months before the screening period, that is, drinking ≥5 standard drinks per day (1 standard drink is equivalent to 120ml wine, 360ml beer or 45ml liquor); * Patients who have abused or become addicted to drugs (narcotics, drugs) in the past year; * Patients with malignant tumors or severe systemic diseases with an expected survival of less than 90 days; * Patients with serious mental disorders or dementia who cannot cooperate to complete informed consent and follow-up; * Participated in any interventional drug or device clinical trials within 3 months prior to screening; * Patients deemed unsuitable for study participation by the investigator;