Iodine as an essential trace element for human, both excessive and insufficient intake would be harmful for human health. As susceptible population, children will be more sensitive to adverse effects caused by inadequate intake of iodine since they are at the peak of growth and development. Meanwhile, there are few direct evidence to establish dietary intakes levels of iodine for 3-6 years old pre-school children.
Eligibility
Sex
ALL
Min age
3 Years
Max age
6 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* for children with mild malnutrition: hemoglobin \<110g / L, or weight for age \<P50 according to the Chinese 2009 child growth and development reference standard, or BMI z score \<-1 according to the WHO Child Growth Assessment Software (version 3.2.2 ) ; have not been treated for thyroid disease; have not used amiodarone and other drugs (including iodine supplements) during the investigation; have no major diseases ,chronic diseases and family history.
* for children with good nutritional status: healthy,-1 \<BMI z score \<1; have not been treated for thyroid disease; have not used amiodarone and other drugs (including iodine supplements) during the investigation; have no major diseases ,chronic diseases and family history;
Exclusion Criteria:
long-term low-protein; long-term low-heat energy malnutrition
Primary outcome measure(s)
urinary iodine concentration — 2 weeks μg/L
diet iodine intake — 2 weeks μg/day
urinary iodine excretion — 2 weeks μg/day
thyroglobulin antibody — 2 weeks IU/mL
salt iodine concentration — 2 weeks μg/L
water iodine intake — 2 weeks μg/day
thyroid volume — 2 weeks ml
Trial sites (1)
Facility
City
Region
Status
Shandong Institute for Endemic Disease Control and Research
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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