Prostatic Urethral Lift: Prostatic urethral lift uses permanent implants to retract the prostate lobes away from the prostate urethra to allow unobstructed passage of urine. These implants are made of Nitinol, non-absorbable monofilament suture material (Poly Ethylene Terephthalate), Stainless Steel
TURP: Using monopolar or bipolar loop diathermy via cystoscopy, excess prostate tissue is resected piecemeal to remove obstruction to the prostatic urethra due to BPH
Study summary
The study will be a prospective, randomized controlled trial comparing prostatic urethral lift (PUL) versus transurethral resection of prostate (TURP) in benign prostate hyperplasia (BPH) patients with urinary retention. The primary objective of this study is to compare the catheter-free rates of PUL vs TURP. Secondary objectives include comparison of complications rates, cost effectiveness, patient satisfactory, symptom scores, quality of life measures and urodynamic parameters.
Eligibility
Sex
MALE
Min age
40 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Male patients
* age \>40 years old
* urinary retention who failed trial without catheter
Exclusion Criteria:
* Inability to provide consent OR no guardians or relatives to help provide consent on patient's behalf
* Active urinary tract infection
* Previous surgical treatment for benign prostatic hyperplasia (i.e., TURP, prostatic urethral lift, etc.)
* Bladder stones
* Urethral strictures or bladder neck contractures
* Prostate size \>100mL
* Solely obstructing median lobe
* Urinary retention not due to obstruction (i.e., Bladder outflow obstruction index \<20 on urodynamic studies)
* Poor detrusor contractility (maximum detrusor pressure \<20cmH2O during voiding phase)
* Anticoagulant or antiplatelet agents that cannot be stopped
Primary outcome measure(s)
Catheter-free rates after prostatic urethral lift versus TURP in BPH patients with urinary retention — 1 year after intervention To determine how many patients will be catheter-free (defined as by the ability to void with a post-void residual urine \<300mL) after intervention and remain catheter-free at 1 month, 3 months, and 1 year after intervention
Trial sites (1)
Facility
City
Region
Status
Queen Mary Hospital
Hong Kong
China
Recruiting
More Queen Mary Hospital, Hong Kong trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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