Second Xiangya Hospital of Central South University
Phase
Observational
Started
2021-02-27
Last updated
2023-06-15
Condition(s) studied
Osteoporosis
Investigational drug(s) / intervention(s)
Regular follow-up
Regular follow-up: Follow-up of the population was conducted to track the incidence of fractures
Study summary
Fracture risk factors have long been identified as key factors in osteoporosis and fragility fractures. The WHO recommended Fracture risk assessmenttool (FRAX) applies clinical risk factors to assess the absolute risk of osteoporotic fractures in each individual. Our preliminary study suggests that FRAX estimates may underestimate the risk of fractures in the Chinese population. In order to optimize the risk prediction model of osteoporotic fractures, a treatment threshold and its optimal cutting point were initially established based on the data of the health management Center of the Second Xiangya Hospital of Central South University.
Eligibility
Sex
ALL
Min age
40 Years
Max age
100 Years
Healthy volunteers
No
Inclusion Criteria:
* Dual-energy X-ray bone mineral density measurement was performed in the health management center of our hospital in the physical examination subjects over 40 years old. Have independent civil capacity and agree to participate, and sign informed consent
Exclusion Criteria:
* Under 40 years of age， Patients who had undergone hip replacement or lumbar surgery and could not perform dual-energy X-ray BMD testing; Patients who have been treated with effective anti-osteoporosis drugs or have a history of malignant tumors.
Primary outcome measure(s)
bone mineral density bone mineral density — From 2021 to 2031 Bone mineral density (BMD) data measured by dual-energy X-ray absorptiometry were collected from patients over 40 years old
Occurrence of fracture — From 2021 to 2031 Follow-up of the population was conducted to track the incidence of fractures
clinical risk factors of osteoporotic fracture — From 2021 to 2031 The main clinical risk factors of osteoporotic fracture were collected
Trial sites (1)
Facility
City
Region
Status
Health Management Center, The Second Xiangya Hospital of Central South University
Changsha
Hunan
Recruiting
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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