A Multicenter Prospective Study of Risk Factors in Progressive Pulmonary Fibrosis

Condition(s) studied

Study summary

The goal of this observational study is to learn about risk of progressive pulmonary fibrosis (PPF). The main questions it aims to answer are:

* Risk factors of PPF
* Prevalence of PPF
* Mortality of PPF

Patients with interstitial lung disease (ILD) of known or unknown etiology other than IPF who has radiological evidence of pulmonary fibrosis will enroll in this study.

* All participants will have baseline investigations at the first visit having provided informed consent.
* At the first visit, baseline characteristics will be collected including demographics, medical history, smoking history, complications and medication use. 50 mL of blood will be obtained. High resolution computed tomography (HRCT), full lung function tests and a 6 min walk test will be performed.
* Further visits at 6 months and 12 months will include further 50 mL blood sampling. HRCT, full lung function tests and a 6 min walk test will be repeated.

Eligibility

Primary outcome measure(s)

• Establish the correlation between Age (years) and progression to PPF — Up to 12 months
• Establish the correlation between Gender (the proportion of female and the proportion of male) and progression to PPF — Up to 12 months
• Establish the correlation between Body mass index (BMI, kg/m2) and progression to PPF — Up to 12 months
• Establish the correlation between ILD-Gender-Age-Physiology score (0-3,4-5 and 6-8) and progression to PPF — Up to 12 months
• Establish the correlation between Artery blood gas and progression to PPF — Up to 12 months
  Artery blood gas: PaCO2 (mmHg) and PaO2 (mmHg)
• Establish the correlation between Pulmonary function and progression to PPF — Up to 12 months
  Pulmonary function: forced vital capacity (FVC, L) and diffusion capacity for carbon monoxide of the lung (DLCO, mmol/min/kPa)
• Establish the correlation between 6 min walk test distance (meters) and progression to PPF — Up to 12 months
• Establish the correlation between Biomarkers and progression to PPF — Up to 12 months
  Biomarkers:CCL18(pg/mL),KL-6(pg/mL),CA125(pg/mL),MMP-7(pg/mL),SP-D(pg/mL) and IL-6(pg/mL)

Trial sites (1)

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