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Clinical Trials in China / NCT05883774
Starting soon Not applicable

Effects of rTMS on the Anxiety State of Older Patients With GAD

NCT05883774 · tracked via the Priya Life Science China tracker
Sponsor
Yi Yang
Phase
Not applicable
Started
2024-12-01
Last updated
2024-10-02

Condition(s) studied

Generalized Anxiety Disorder

Investigational drug(s) / intervention(s)

Repetitive Transcranial Magnetic StimulationSham Repetitive Transcranial Magnetic Stimulation

Repetitive Transcranial Magnetic Stimulation: rTMS is applied using a transcranial magnetic stimulator with a figure-of-8 coil once per day for 10 consecutive days. rTMS is delivered to the right dorsolateral prefrontal cortex (DLPFC) at a frequency of 1 Hz for 20 minutes (1200 total pulses).

Sham Repetitive Transcranial Magnetic Stimulation: Sham-rTMS is performed in the same way as the treatment group except that the coil is rotated 90° away from the scalp.

Study summary

The purpose of this study is to evaluate the effects of low-frequency repetitive transcranial magnetic stimulation on anxiety state in older patients with generalized anxiety disorder.

Eligibility

Sex
ALL
Min age
60 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * 1)Age≥60 years, regardless of gender. * 2)Meets the diagnostic criteria for generalized anxiety disorder in the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-V) developed by the American Psychiatric Association. * 3)HAMA score≥14 and HAMD-17 items score \<17. * 4)No adjustment in the type and dose of anti-anxiety medication in the 3 months prior to randomization. * 5)Willing to participate and sign the informed consent. Exclusion Criteria: * 1)Traumatic brain injury or other conditions affecting the brain, such encephalitis, brain tumors, or intracranial hypertension. * 2)Previous history of epilepsy, family history of epilepsy or presence of seizure provoking factors or alcohol abuse. * 3)History of other psychiatric disorders such as current post-traumatic stress disorder, substance use disorder (within 6 months), bipolar disorder and obsessive-compulsive disorder. * 4)Unstable mental state with impulses toward self-harm or suicide. * 5)Presence of intracranial metal implant, cochlear implant, built-in pulse generator (such as cardiac pacemaker), etc. * 6)Medical or surgical disorders that are severe or unstable. * 7)Pregnancy or breastfeeding. * 8\) Those who are participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to enrollment. * 9\) Other conditions that the researchers think are not suitable for the project.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
First Hospital of Jilin University Changchun Jilin

More Yi Yang trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05883774 on ClinicalTrials.gov ↗ ← All trials in China