Repetitive Transcranial Magnetic StimulationSham Repetitive Transcranial Magnetic Stimulation
Repetitive Transcranial Magnetic Stimulation: rTMS is applied using a transcranial magnetic stimulator with a figure-of-8 coil once per day for 10 consecutive days. rTMS is delivered to the right dorsolateral prefrontal cortex (DLPFC) at a frequency of 1 Hz for 20 minutes (1200 total pulses).
Sham Repetitive Transcranial Magnetic Stimulation: Sham-rTMS is performed in the same way as the treatment group except that the coil is rotated 90° away from the scalp.
Study summary
The purpose of this study is to evaluate the effects of low-frequency repetitive transcranial magnetic stimulation on anxiety state in older patients with generalized anxiety disorder.
Eligibility
Sex
ALL
Min age
60 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* 1)Age≥60 years, regardless of gender.
* 2)Meets the diagnostic criteria for generalized anxiety disorder in the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-V) developed by the American Psychiatric Association.
* 3)HAMA score≥14 and HAMD-17 items score \<17.
* 4)No adjustment in the type and dose of anti-anxiety medication in the 3 months prior to randomization.
* 5)Willing to participate and sign the informed consent.
Exclusion Criteria:
* 1)Traumatic brain injury or other conditions affecting the brain, such encephalitis, brain tumors, or intracranial hypertension.
* 2)Previous history of epilepsy, family history of epilepsy or presence of seizure provoking factors or alcohol abuse.
* 3)History of other psychiatric disorders such as current post-traumatic stress disorder, substance use disorder (within 6 months), bipolar disorder and obsessive-compulsive disorder.
* 4)Unstable mental state with impulses toward self-harm or suicide.
* 5)Presence of intracranial metal implant, cochlear implant, built-in pulse generator (such as cardiac pacemaker), etc.
* 6)Medical or surgical disorders that are severe or unstable.
* 7)Pregnancy or breastfeeding.
* 8\) Those who are participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to enrollment.
* 9\) Other conditions that the researchers think are not suitable for the project.
Primary outcome measure(s)
Differences in HAMA scores after 10 sessions of rTMS/sham-rTMS between two groups. — baseline; 10 days The HAMA scale consists of 14 items, each with a score ranging from 1 to 4, for a total score ranging from 14 to 56, and the degree of anxiety correlates positively with the score.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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