Efficacy of Electroacupuncture Versus Solifenacin Succinate for Female Overactive Bladder

Condition(s) studied

Investigational drug(s) / intervention(s)

electroacupuncture: All acupuncture locations will be sterilized on a routine basis. As acupuncture needles are inserted, all needles will be lifting, twirling, and thrusting to reach de qi, a sensation generally associated with acupuncture, including swelling, soreness, numbness, and heaviness. An electrical stimulator is applied to ipsilateral BL32 and BL35 (KI12 and ST28) with continuous waves of 30 Hz and currents of 1 to 5.0 mA. During the study, oral Solifenacin Succinate placebo will be used.

Solifenacin Succinate Tablets: During the study, participants will take Solifenacin Succinate. The acupuncture points are the same as the electroacupuncture group, without the insertion of needles. The procedures, electrode positions and other treatment settings are the same as the electroacupuncture group, without the skin penetration, power output or needle manipulation of the de qi. At the end of the treatment, the acupuncturist will press the acupuncture point with a dry cotton ball to allow the patient to feel the "needles"being pulled out.

Study summary

Through a scientific and standardized multicenter, blinding, double-dummy, randomized controlled, noninferiority clinical trial study method, the investigators evaluated electroacupuncture as a safe and effective non-pharmacological treatment for OAB in women by comparison with Solifenacin Succinate.

Eligibility

Primary outcome measure(s)

• the percentage change in the number of voids every 24 hours at week 4. — At week 4 (end of treatment).
  The percentage change in the number of voids every 24 hours at week 4 compared to baseline. It is measured by a three-day voiding diary.

Trial sites (1)

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