All pregnant women with a twin pregnancy and the offspring
All pregnant women with a twin pregnancy and the offspring: No intervention
Study summary
Twin pregnancy increases the risk of maternal and fetal complications, which include gestational hypertension, premature labor, twin-to-twin transfusion syndrome, intrauterine growth restriction, anemia, amniotic fluid abnormalities. Comprehensively understanding the molecular mechanisms of the disease and identification of markers contribute to development of novel therapeutic approaches. In addition, the twin pregnancy, especially the monochorionic, is an essential model of "experiments of nature". This model can be applied to distinguish the epigenetic differences of twins in utero and after birth in the same genomic context. The aim of the study is to constitute a prospective cohort of twin pregnancies and the offspring.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
1. Maternal age \>18 years old.
2. Twin pregnancy.
Exclusion Criteria:
1. Fetal chromosomal or congenital abnormalities.
2. Stillbirth.
Primary outcome measure(s)
The incidence of maternal and fetal complications — From confirmation of pregnancy to 42 days postpartum The incidence of preeclampsia, gestational diabetes mellitus, premature delivery, postpartum hemorrhage, twin to twin transfusion syndrome, selective intrauterine growth restriction.
RNA profiles in placentas of twin pregnancy measured by RNA-sequencing — Immediately after delivery Levels of placental RNA expression.
Global DNA methylation in placentas of twin pregnancy measured by whole-genome bisulfite sequencing — Immediately after delivery Global DNA methylation levels in placentas of twin pregnancy.
Protein profiles in placentas of twin pregnancy measured by tandem mass tags quantification. — Immediately after delivery Levels of proteins in placentas of twin pregnancy.
Post-translation modification of proteins in placentas of twin pregnancy measured by Integrative use of phosphoproteomics, ubiquitylproteomics and acetylproteomics. — Immediately after delivery Post-translational levels of proteins in placentas of twin pregnancy.
Metabolite profiles in placentas of twin pregnancy measured by metabolomics — Immediately after delivery Metabolite profiles in placentas of twin pregnancy.
Lipid profiles in placentas of twin pregnancy measured by lipidomic analysis — Immediately after delivery Lipid profiles in placentas of twin pregnancy.
Predictive protein markers of maternal and fetal complications in maternal blood measured by tandem mass tags quantification — From confirmation of pregnancy to 42 days postpartum Levels of specific proteins in maternal blood.
Predictive RNA markers of maternal and fetal complications in maternal blood measured by RNA-sequencing — From confirmation of pregnancy to 42 days postpartum Levels of specific RNAs in maternal blood.
Predictive metabolite markers of maternal and fetal complications in maternal blood measured by metabolomics — From confirmation of pregnancy to 42 days postpartum Levels of specific metabolites in maternal blood.
Predictive lipid markers of maternal and fetal complications in maternal blood measured by lipidomic analysis — From confirmation of pregnancy to 42 days postpartum Levels of specific lipids in maternal blood.
Trial sites (1)
Facility
City
Region
Status
Obstetrics and Gynecology Hospital of Fudan University
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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