A birth cohort study to evaluate the role of human microbiome and vitamin D in the development of allergic diseases in young child before one year of age.
Eligibility
Sex
ALL
Min age
0 Years
Max age
1 Year
Healthy volunteers
Accepted
Inclusion Criteria:
* All term newborn babies who are born in China Medical University Hospital. The term baby defines the maternal gestational age between 37 0/7 weeks to 41 6/7 weeks.
Exclusion Criteria:
* The exclusion criteria are prematurity newborn, congenital anomalies and cardiopulmonary failure need for resuscitation immediately after birth.
Primary outcome measure(s)
Microbiome — Month 0 Meconium samples will be used to detect intestinal microbiome by using 16S rRNA sequencing to determine baseline status.
Microbiome — Month 2 Nasal and anal swabs will be used to detect respiratory and intestinal microbiome by using 16S rRNA sequencing to determine baseline status.
Microbiome — Month 12 Nasal and anal swabs will be used to detect respiratory and intestinal microbiome by using 16S rRNA sequencing,and to follow the change from baseline in microbiome at month 12.
Levels of vitamin D — Month 12 Vitamin D will be measured in a blood sample by ELISA.
Single nucleotide polymorphism of vitamin D receptor and vitamin D binding protein — Month 12 Single nucleotide polymorphism (SNP) genotyping will be performed in a blood sample by using TaqMan SNP genotyping assays.
Total immunoglobulin E (IgE) — Month 12 Plasma total IgE concentration will be measured by microparticle immunoassay (IMx analyzer, Abbott Laboratories, Abbott Park, IL) and ELISA.
Allergen-specific immunoglobulin E (IgE) — Month 12 Plasma allergen-specific IgE will be measured by BioIC ®.
Trial sites (1)
Facility
City
Region
Status
China Medical University Hospital
Taichung
Taiwan
Recruiting
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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