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Clinical Trials in China / NCT05560373
Starting soon Phase 4

The Effect of Huperzine A Injection on Postoperative Cognitive Dysfunction in Patients With Aneurysmal Subarachnoid Hemorrhage: a Pilot Study

NCT05560373 · tracked via the Priya Life Science China tracker
Sponsor
Wanbangde Pharmaceutical Group Co., LTD
Phase
Phase 4
Started
2026-12-31
Last updated
2026-08-17

Condition(s) studied

Postoperative Cognitive Dysfunction in Patients With Aneurysmal Subarachnoid Hemorrhage

Investigational drug(s) / intervention(s)

Huperzine A injection, operational treatment, the best basic treatmentoperational treatment, the best basic treatmentHuperzine A injection, interventional treatment, the best basic treatmentInterventional treatment, the best basic treatment

Huperzine A injection, operational treatment, the best basic treatment: intramuscular

operational treatment, the best basic treatment: other

Huperzine A injection, interventional treatment, the best basic treatment: intramuscular

Interventional treatment, the best basic treatment: other

Study summary

Under the premise of basic treatment, to explore the improvement effect of huperzine A injection on short-term and long-term neurocognitive dysfunction in patients with aneurysmal subarachnoid hemorrhage after interventional/surgical treatment.

Eligibility

Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
No
Inclusion Criteria: * Age 18-70; * The patients were proved to be aneurysmal subarachnoid hemorrhage by imaging examination (head CT, CT angiography (CTA), whole brain angiography (DSA)); * Hunt Hess was graded I-III at admission; * The patients were treated with endovascular therapy or craniotomy and clipping surgery; * The time from the onset of aSAH symptoms to admission ≤ 72 hours; ⑥ The subject himself or the guardian of the subject knew and voluntarily signed the informed consent form. Exclusion Criteria: * Non aneurysmal subarachnoid hemorrhage; * Cognitive dysfunction existed before onset; * Patients with angina pectoris, bronchial asthma, mechanical intestinal obstruction, liver and kidney insufficiency, and urinary tract obstruction; * Complicated with other nervous system diseases, including nervous system degenerative diseases (Alzheimer's disease, Parkinson's disease, Lewy body dementia, frontotemporal dementia, etc.), neuromyelitis optica, epilepsy, central nervous system infection (such as AIDS, syphilis, etc.), brain traumatic dementia, etc; * Psychotic patients, according to DSM-IV-TR standards, including schizophrenia or other mental diseases, bipolar disorder, major depression or delirium; * Other cholinesterase inhibitor drugs are being used; ⑦ There are uncorrectable visual and auditory disorders, and neuropsychological tests and scales cannot be completed; * Have unstable or serious heart, lung, liver, kidney and hematopoietic system diseases; * Pregnant or lactating women and women of childbearing age without reliable contraception, and there is no evidence of negative pregnancy; ⑩ Patients who cannot be followed up as required during the study period; ⑪ Those who are allergic to the test drug; ⑫ Those who have participated in other clinical trials in recent 3 months; ⑬ Patients who are not suitable to participate in the clinical trial.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang

More Wanbangde Pharmaceutical Group Co., LTD trials in China

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05560373 on ClinicalTrials.gov ↗ ← All trials in China