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Clinical Trials in China / NCT05363800
Active, not recruiting Phase 1

Phase I Study of HRS-3738 in Recurrent and Refractory Non-Hodgkin's Lymphoma and Multiple Myeloma

NCT05363800 · tracked via the Priya Life Science China tracker
Sponsor
Jiangsu HengRui Medicine Co., Ltd.
Phase
Phase 1
Started
2022-06-17
Last updated
2026-06-05

Condition(s) studied

Recurrent and Refractory Non-Hodgkin's Lymphoma and Multiple Myeloma

Investigational drug(s) / intervention(s)

HRS-3738

HRS-3738: HRS-3738 will be administrated per dose level in which the patients are assigned.

Study summary

This study is an open-label, multicenter Phase I clinical trial to evaluate the safety, tolerability, pharmacokinetics and efficacy of HRS-3738 in patients with recurrent and refractory Non-Hodgkin's lymphoma and multiple myeloma.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: 1. Active multiple myeloma in accordance with IMWG criteria,or histopathologically and immunohistochemically confirmed non-Hodgkin's lymphoma in accordance with the 2016 WHO Classification of lymphoid neoplasias. 2. Recurred or did not alleviate after the previous treatment. 3. Have at least one measurable lesion. 4. With a life expectancy of ≥3 months. 5. Male or female ≥ 18 years old. 6. ECOG performance status of 0-1. 7. Subjects must voluntarily agree to participate in the trial and sign a written informed consent form. Exclusion Criteria: 1. Amyloidosis, plasma cell leukemia. 2. Corrected serum calcium\>3.4mmol/L(13.5mg/dl). 3. Presence of metastasis to central nervous system. 4. Treatment of other investigational products. 5. Major surgical therapy within 28 days prior to the date of signature of informed consent form, or expected major surgery during the study. 6. Known history of hypersensitivity to any components of HRS-3738. 7. Other factors that may affect the study results or lead to forced termination of the study early as judged by investigators.

Primary outcome measure(s)

Trial sites (3)

FacilityCityRegionStatus
Henan cancer Hospital Zhengzhou Henan
Sheng Jing Hospital of China Medical University Shengyang Liaoning
Zhejiang University School of Medicine The First Affiliated Hospital Hangzhou Zhejiang

More Jiangsu HengRui Medicine Co., Ltd. trials in China

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05363800 on ClinicalTrials.gov ↗ ← All trials in China