Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Phase
Not applicable
Started
2023-05-01
Last updated
2026-04-24
Condition(s) studied
Cesarean Section; Dehiscence
Investigational drug(s) / intervention(s)
Leuprorelin
Leuprorelin: Leuprorelin will be used to postpone period after vaginal repair.
Study summary
GnRH-a will be used to postpone period after vaginal repair for Cesarean Section Scar Defect（CSD） patients with adenomyosis which will be compared with CSD patients with adenomyosis who receive transvaginal surgery without GnRH-a, whether delayed period improving the CSD prognosis will be assessed.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
50 Years
Healthy volunteers
No
Inclusion Criteria:
1. Clearly diagnosed with CSD complicated with adenomyosis
2. Experiencing clinical features of abnormal uterine bleeding, prolonged menstrual flow (the duration of menstruation is more than 10 days).
3. The thickness of the remaining muscular layer of CSD was less than 3 mm.
4. Normal range of blood sugar and insulin
5. No serious medical problems (important viscera function in the normal range).
6. uterine fibroids no more than 5cm
7. Sign the informed consent.
Exclusion Criteria:
1. Indefinite diagnosis.
2. Malignant tumors.
3. With severe medical problems (severe liver disease, kidney disease, respiratory diseases, heart disease or uncontrolled diabetes, epilepsy, etc., dysfunction of important organs).
4. Pregnant.
5. Mental diseases.
6. Allergy to the any ingredients of Leuprorelin
7. Unwilling to comply with the research plan.
Primary outcome measure(s)
thickness of the remaining muscular layer (TRM) (mm) — 12 weeks after vaginal repair of CSD The thickness of the remaining muscular layer is measured by magnetic resonance imaging (MRI)
Duration of menstruation (day) — 12 weeks after vaginal repair of CSD Duration of menstruation (day)
Trial sites (1)
Facility
City
Region
Status
Shanghai Jiaotong University xinhua hospital
Shanghai
Shanghai Municipality
Recruiting
More Xinhua Hospital, Shanghai Jiao Tong University School of Medicine trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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