Combined Aerobic Exercise and Cognitive Training in Seniors at Increased Risk for Alzheimer's Disease

Condition(s) studied

Investigational drug(s) / intervention(s)

Combined aerobic exercise and cognitive training program: Participants will take part in a combined aerobic exercise and cognitive training program. The program will include moderate cycling exercise and cognitive game resolving at the same time. The tasks will be instructed and supervised by a fitness expert and a trained clinical neuropsychologist.

Study summary

The study aims to investigate the effect of a long-term combined aerobic exercise and cognitive training program on cognitive function and blood exosomal synaptic protein levels in seniors at increased risk for Alzheimer's Disease.

Eligibility

Primary outcome measure(s)

• Change in cognitive function over time as assessed by the Montreal Cognitive Assessment (MoCA) — baseline time, year 1, year 3, year 5, year 7
  MoCA will be performed to evaluate the cognition of participants at the enrollment and year 1, year 3, year 5, year 7. The score ranges from 0 to 30, with higher values indicating better cognition.
• Change in cognitive function over time as assessed by Mini Mental State Examination (MMSE) — baseline time, year 1, year 3, year 5, year 7
  MMSE will be performed to evaluate the cognition of participants at the enrollment and year 1, year 3, year 5, year 7. The score ranges from 0 to 30, with higher values indicating better cognition.
• Change in cognitive function over time as assessed by Clinical Dementia Rating (CDR) — baseline time, year 1, year 3, year 5, year 7
  CDR will be performed to evaluate the cognition of participants at the enrollment and year 1, year 3, year 5, year 7. The score ranges from 0 to 18, with higher values indicating worse cognition.
• Change in cognitive function over time as assessed by Verbal Fluency Test — baseline time, year 1, year 3, year 5, year 7
  Verbal Fluency Test will be performed to evaluate the semantic memory function of participants at the enrollment and year 1, year 3, year 5, year 7. Participants are asked to produce as many animals as possible within 1 minute. The score is the number of animals, with higher scores indicating better cognition.
• Change in cognitive function over time as assessed by Digit Span Test-Forward and Backward — baseline time, year 1, year 3, year 5, year 7
  Digit Span Tests will be performed to evaluate the working memory of participants at the enrollment and year 1, year 3, year 5, year 7. The total scores are twelve for each test, with higher values indicating better cognition.
• Change in cognitive function over time as assessed by Trail-Making Test Parts A and B (TMT-A and TMT-B) — baseline time, year 1, year 3, year 5, year 7
  TMT-A and TMT-B will be performed to evaluate the executive function of participants at the enrollment and year 1, year 3, year 5, year 7. Scoring is based on time taken to complete the test (e.g., 35 seconds yielding a score of 35), with lower scores indicating better cognition.
• Change in cognitive function over time as assessed by Boston Naming Test (BNT) — baseline time, year 1, year 3, year 5, year 7
  BNT will be performed to evaluate the language function of participants at the enrollment and year 1, year 3, year 5, year 7. The score ranges from 0 to 30, with higher values indicating better cognition.
• Change in cognitive function over time as assessed by the Rey-Osterrieth Complex Figure Test (ROCF) — baseline time, year 1, year 3, year 5, year 7
  ROCF will be performed to evaluate the visuospatial function and other cognition domains of participants at the enrollment and year 1, year 3, year 5, year 7. Participants are asked to produce a complicated line drawing, with higher scores indicating better cognition.
• Change in cognitive function over time as assessed by California Verbal Learning Test (CVLT) — baseline time, year 1, year 3, year 5, year 7
  CVLT will be performed to evaluate the memory function of participants at the enrollment and year 1, year 3, year 5, year 7. Participants are asked to finish immediate recall, delayed recall, and delayed recognition tasks in the test, with higher scores indicating better cognition.

Trial sites (1)

More Xuanwu Hospital, Beijing trials in China

Other trials for the same condition