Chemoradiotherapy Sequenced Radical Surgery for Colorectal Cancer With PALNM

Condition(s) studied

Investigational drug(s) / intervention(s)

Radical surgery with PALND: sufficient resection margins of the tumor, D3 dissection of the regional lymph nodes and para-aortic lymph node dissection from the bifurcation of iliac artery to the left renal vein via laparoscopic approach

Radical surgery without PALND: surgery includes sufficient resection margins of the tumor and D3 dissection of the regional lymph nodes without PALND

Study summary

In left-sided colon and rectal cancer, the occurrence of synchronous para-aortic lymph node metastasis is rare, with the incidence of being approximate 1-2%. Currently, there has been no standard treatment strategy for this situation. The present trial is designed to evaluate the safety and efficacy of para-aortic lymph node dissection for left-sided colon and rectal cancer with synchronous para-aortic lymph node metastasis

Eligibility

Primary outcome measure(s)

• 5-year OS — From date of recruitment until the date of death from any cause, assessed up to 5 years
  5-year overall survival

Trial sites (1)

More Qilu Hospital of Shandong University trials in China

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