🇮🇪Ireland
16°C Partly Cloudy · Dublin
Live Updates
--:--:-- IST
Writer Login
Latest
Clinical Trials in China / NCT05112965
Active, not recruiting Phase 3

An Extension Study in Participants Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study (IMbrella C)

NCT05112965 · tracked via the Priya Life Science China tracker
Sponsor
Hoffmann-La Roche
Phase
Phase 3
Started
2021-12-01
Last updated
2026-07-06

Condition(s) studied

Neoplasms

Investigational drug(s) / intervention(s)

AtezolizumabBevacizumabPemetrexedPaclitaxelEnzalutamide

Atezolizumab: Atezolizumab will be administered as a monotherapy or atezolizumab with other agent(s) as per parent protocol. Dosing regimen will continue in accordance with the parent study or at equivalent dose (if applicable) and at the same schedule as the parent study at the time of participant discontinuation from the parent study closure.

Bevacizumab: Bevacizumab will be administered as directed per the parent study.

Pemetrexed: Pemetrexed will be administered as directed per the parent study.

Paclitaxel: Paclitaxel will be administered as directed per the parent study.

Enzalutamide: Enzalutamide will be administered as directed per the parent study.

Study summary

This is an open-label, multicenter, non-randomized extension study. Participants receiving atezolizumab monotherapy or atezolizumab combined with other agent(s) or comparator agent(s) in a Genentech or Roche-sponsored study (the parent study), who are eligible to continue treatment and do not have access to the study treatment locally, continue to receive study treatment in this extension study.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * Eligible for continuing or crossing over to atezolizumab-based therapy at the time of rollover from the parent study, as per the parent study protocol, or * Eligible for continuing the comparator agent(s) in a Genentech- or Roche-sponsored study as per the parent study protocol, with no access to commercially available comparator agent * First dose of study treatment in this extension study will be received within 7 days of the treatment interruption window allowed by the parent study * Continue to benefit from atezolizumab-based study treatment or from the comparator at the time of rollover from the parent study as assessed by the investigator * Negative serum pregnancy test within 7 days prior to start of study treatment in women of childbearing potential * For women of childbearing potential: agreement to remain abstinent or use contraceptive methods, and agreement to refrain from donating eggs * For men: agreement to remain abstinent or use contraceptive measures, and agreement to refrain from donating sperm Exclusion Criteria: * Meet any of the study treatment discontinuation criteria specified in the parent study at the time of enrollment in the extension study * Study treatment is commercially marketed in the patient's country for the patient-specific disease and is accessible to the patient * Time between the last dose of treatment received in parent study and first dose in extension study is longer than the interruption period (±7 days) allowed in the parent study * Treatment with any anti-cancer treatment (other than treatment permitted in the parent study) during the time between last treatment in the parent study and the first dose of study treatment in the extension study * Permanent discontinuation of atezolizumab for any reason during the parent study or during the time between last treatment in the parent study and the first dose of study treatment in the extension study (if applicable) * Any unresolved or irreversible toxicities during the parent study that required permanent discontinuation of study treatment, in accordance to the parent study or local prescribing information * Ongoing serious adverse events that have not resolved to baseline level or Grade ≤1 from the parent study or during the time between the last treatment in the parent study and the first dose of study treatment in the extension study * Any serious uncontrolled concomitant disease that would contraindicate the use of study treatment at the time of the extension study or that would place the patient at high risk for treatment-related complications * Concurrent participation in any therapeutic clinical trial (other than the parent study) * Pregnant or lactating, or intending to become pregnant during the extension study

Primary outcome measure(s)

Trial sites (17)

FacilityCityRegionStatus
Nanfang Hospital, Southern Medical University Guangzhou Guangdong
Harbin Medical University Cancer Hospital Harbin Heilongjiang
Union Hospital of Tongji Medical College, Dept. of Cancer Center Wuhan Hubei
Cancer Hospital of Shandong First Medical University Jinan Shandong
Sir Run Run Shaw Hospital Hangzhou Zhejiang
Beijing Cancer Hospital Beijing China
Peking Union Medical College Hospital Beijing China
Changchun Cancer Hospital Changchun China
Jilin Cancer Hospital Changchun China
Hunan Cancer Hospital Changsha China
The First Affiliated Hospital of Guangzhou Medical University Guangzhou China
Jiangsu Cancer Hospital Nanjing China
Shanghai Chest Hospital Shanghai China
Tianjin Cancer Hospital Tianjin China
The 2nd Hospital of Tianjin Medical University Tianjin China
Zhejiang Cancer Hospital Zhejiang China
Henan Cancer Hospital Zhengzhou China

On this site

📄 Tecentriq (atezolizumab) drug profile → 📄 Avastin (bevacizumab) drug profile → 📄 Xtandi (enzalutamide) drug profile →

More Hoffmann-La Roche trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05112965 on ClinicalTrials.gov ↗ ← All trials in China