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Clinical Trials in China / NCT04872660
Recruiting Phase 4

Efficacy and Safety of Gushen Antai Pill on Ongoing Pregnancy Rate in Women With Normal Ovarian Reserve Undergoing IVF-ET

NCT04872660 · tracked via the Priya Life Science China tracker
Sponsor
Shandong University of Traditional Chinese Medicine
Phase
Phase 4
Started
2021-06-15
Last updated
2026-03-10

Condition(s) studied

Infertility, Female

Investigational drug(s) / intervention(s)

Gushen Antai PillPlacebo pill

Gushen Antai Pill: The Gushen Antai Pill (GSATP, Z20030144) is composed of 10 herbs including radix-polygoni multiflori, radix rehmanniae praeparata, cistanche salsa, radix dipsaci, uncaria, semen cuscutae, rhizoma atractylodis macrocephalae, radix scutellariae, radix paeoniae lactiflorae. Its production follows GMP standards and takes the form of water honey pills, each bag of 6g.

Placebo pill: The placebo pill is produced by Beijing boran Pharmaceutical Co., Ltd. It can simulate the appearance, color and smell of GSATP formula, but it has no clinical effect because it has no active ingredients.

Study summary

The purpose of this study is to investigate whether oral Gushen Antai pills supplementation for luteal phase support will improve ongoing pregnancy rate in women with normal ovarian reserve in fresh embryo transfer cycles.

Eligibility

Sex
FEMALE
Min age
21 Years
Max age
42 Years
Healthy volunteers
No
Inclusion Criteria: * Patients with normal ovarian function reserve (5 ≤ AFC ≤ 15, 1.2 ng/ml ≤ AMH ≤ 3.5 ng/ml). * Patients with regular menstrual cycle (21-35 days) and normal ovulation. * Initial IVF / ICSI treatment. * At least one embryo or blastocyst available for transfer. Exclusion Criteria: * Age ≥ 43 years old. * Body mass index (BMI) ≥ 28 Kg/m2. * "Freeze-all" strategy. * Those using the natural cycle or mild stimulation for IVF/ICSI treatment. * Individuals with severe hyperstimulation ovarian syndrome during controlled ovarian stimulation. * Acceptors of donated oocytes or performed either In vitro Maturation (IVM) or blastocyst biopsy for Preimplantation Genetic Diagnosis (PGD) or Preimplantation Genetic Testing for Aneuploidies (PGT-A). * History of two or more previous consecutive spontaneous abortions. * History of two or more previous IVF-ET failures. * Karyotype abnormalities. * Polycystic ovary syndrome. * Presence of a non-surgically treated hydrosalpinx, uterine cavity fluid or endometrial polyp and an ovarian endometriosis cyst requiring surgery, during ovarian stimulation. * Congenital or acquired abnormalities of uterine anatomy. * Combined contraindications to assisted reproductive technology or pregnancy, such as uncontrolled abnormalities of liver and kidney function, diabetes mellitus (glycosylated haemoglobin ≤7%, fasting blood glucose \<10 mmol/L ), hypertension, thyroid disease, symptomatic heart disease, moderate to severe anaemia, history of malignancy or thromboembolism or propensity to thrombosis, severe psychiatric disorder, acute infections of the genitourinary system, sexually transmitted diseases, serious adverse habits such as drug abuse, exposure to teratogenic amounts of radiation, toxins, or drugs (such as prednisone or other hormones, adrenaline, antibiotics, or hypertension, cardiovascular, or antiviral medications) during the active procedure period , and uterine factor infertility or physical illness which prevents the ability to bear a pregnancy.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
The Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan Shandong Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04872660 on ClinicalTrials.gov ↗ ← All trials in China