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Clinical Trials in China / NCT04533295
Recruiting Not applicable

Effect of Acupuncture on IVF Pregnancy Outcomes for Women With RIF

NCT04533295 · tracked via the Priya Life Science China tracker
Sponsor
Huazhong University of Science and Technology
Phase
Not applicable
Started
2020-11-02
Last updated
2026-03-10

Condition(s) studied

Repeated Implantation Failure

Investigational drug(s) / intervention(s)

acupuncture and IVFsham acupuncture and IVFcontrol group

acupuncture and IVF: Acupuncture was performed three times a week for 30 minutes each time, starting from the 5th day of menstruation before the cycle of the transfer and ending within 24 hours after embryo transfer.

sham acupuncture and IVF: Sham acupuncture was performed three times a week for 30 minutes each time, starting from the 5th day of menstruation before the cycle of the transfer and ending within 24 hours after embryo transfer.

control group: no acupuncture, only IVF

Study summary

The randomized, placebo-controlled multicenter trial is conducted in five centers in China. After screening and obtaining the signed informed consent , the participants are randomly divided into three groups: acupuncture group (Acu.+IVF),sham acupuncture group(Sham Acu. +IVF),and the control group (only IVF).

Eligibility

Sex
FEMALE
Min age
25 Years
Max age
40 Years
Healthy volunteers
No
Inclusion Criteria: 1. Married women aged 25-40; 2. Repeated implantation failure for unknown reasons (experienced 2 or more embryo transfers of good-quality embryos without achieving clinical pregnancy); 3. Transplantable Day 3 high-quality frozen embryos or frozen blastocysts (≥3BB); 4. Estrogen and progesterone replacement therapy (HRT), endometrial thickness ≥7mm on the day of endometrial transformation. Exclusion Criteria: Patients who met any of the following conditions were not included. 1. Those who prepare for PGD; 2. Recipients of egg donors; 3. Chromosomal abnormalities in both or one of the couples (excluding chromosome polymorphism); 4. patients with implantation failure due to known embryonic factors; 5. Uterine lesions that may affect implantation (including uterine malformation, \>4cm intramural fibroids,submucosal fibroids, adenomyosis, uterine tuberculosis, intrauterine adhesions, etc. 6. Repeated spontaneous abortion (2 or more fetal loss before 28 weeks of gestation); 7. Patients with other endocrine diseases, such as thyroid disease, hyperprolactinemia, insulin resistance, diabetes, adrenal disease, etc., and poor control of hormone levels in the last 3 months; 8. Clearly diagnosed autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, etc.; 9. Hydrosalpinx untreated; 10. BMI less than 18 or higher than 25kg/m2; 11. People with previous history of needle sickness; 12. Those who have previously participated in this study or received acupuncture treatment in the past 3 months. 13. Any situation that researchers consider inappropriate for participating in this study.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Tongji Hospital,Tongji medical college,HUST Wuhan Hubei Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04533295 on ClinicalTrials.gov ↗ ← All trials in China