The Research About Acute Compartment Syndrome

Condition(s) studied

Investigational drug(s) / intervention(s)

fasciotomy: if it was suspected with ACS, the fasciotomy was conducted. but if the blister observed, it means decreased conmpartment sydrome. therefore, the blister observed can avoid unnecessary fasciotomy to patients suspected with ACS

Study summary

Acute compartment syndrome (ACS) is defined as a clinical entity originated from trauma or other conditions, and remains challenging to diagnose and treat effectively. Threre is the controversy in diagnosing, treating ACS. It was found that there was no criterion about the ACS, and result unnecessary osteotomy. The presence of clinical assessment (5P) always means the necrosis of muscles and was the most serious or irreversible stage of ACS. Besides pressure methods, the threshold of pressure identifying ACS was also controversial.

Eligibility

Primary outcome measure(s)

• injury mechanism — up to 1 weeks
  The relative data was collected about injury mechanism such as high falling accident, traffic accident, fall from standing height,Crushing
• the time when the blister appeared — up to 4 weeks
  The relative data was collected about the time when the blister appeared after injury
• time to reconstructive surgery — time to when the surgery was conducted after 2 weeks
  The relative data was collected about time to reconstructive surgery
• union time — through study completion, an average of 1 year
  The relative data was collected about union time
• No non-anatomic gap or step (larger than 5 mm) — through study completion, an average of 1 year
  The relative data was collected about complications
• secondary loss of reduction — through study completion, an average of 1 year
  The relative data was collected about complications
• Deep venous thrombosis — through study completion, an average of 1 year
  The relative data was collected about complications
• superficial wound problems — through study completion, an average of 1 year
  The relative data was collected about complications
• blister skin immunochemistry and immunofluorescence analysis — through study completion, an average of 1 year
  CK1, 5, 10, claudin 1, 2 and occludin as determined by immunochemistry analysis, and skin barrier proteins; claudin 1, 2 and occludin was determined by immunofluorescence analysis and qPCR.

Trial sites (1)

More Hebei Medical University Third Hospital trials in China

Other trials for the same condition