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Clinical Trials in China / NCT04486859
Active, not recruiting Not applicable

Postoperative Thrombosis Prevention in Patients With CD

NCT04486859 · tracked via the Priya Life Science China tracker
Sponsor
Huashan Hospital
Phase
Not applicable
Started
2020-12-01
Last updated
2025-07-02

Condition(s) studied

Cushing DiseaseDVTPulmonary Embolism

Investigational drug(s) / intervention(s)

LMWH/RivaroxabanIPC

LMWH/Rivaroxaban: combined prevention

IPC: mechanical prevention

Study summary

Patients with Cushing disease was randomized to 2 groups. After surgery, the patients were managed with mechanical prevention or mechanical prevention plus anticoagulant drugs(LMWH followed by rivaroxaban), VTE was observed 24h, 5day, 4weeks and 12weeks after surgery.Bleeding events were also recorded.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: * Cushing\'s disease diagnosed and treated with transsphenoid surgery at study centers Exclusion Criteria: 1. History of VTE before surgery or within 24 hours post-surgery 2. Acute bacterial endocarditis 3. Major bleeding events 4. Thrombocytopenia 5. Active gastrointestinal ulcers 6. History of stroke 7. High risk of bleeding due to clotting abnormalities 8. Participation in other clinical trials within the last three months 9. Contraindications to rivaroxaban (e.g., renal dysfunction with eGFR \< 50 mL/min) 10. Presence of other malignant diseases 11. Severe mental or neurological disorders 12. Presence of intracranial vascular abnormalities 13. Contraindications to mechanical prophylactic anticoagulation 14. Pregnancy 15. Any other condition that researchers deem inappropriate for study participation.

Primary outcome measure(s)

Trial sites (7)

FacilityCityRegionStatus
The First Affiliated Hospital of Fujian Medical University Fuzhou Fujian
The First Affiliated Hospital of Sun Yat sen University Guangzhou Guangdong
Tongji Hospital Wuhan Hubei
Huashan Hospital Shanghai Shanghai Municipality
China West Hospital Chengdu Sichuan
People's Hopital of Xinjiang Uygur Autonomous Region Ürümqi Xinjiang
Peking Union Medical College Hospital Beijing China

More Huashan Hospital trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04486859 on ClinicalTrials.gov ↗ ← All trials in China