Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Phase
Observational
Started
2018-05-21
Last updated
2026-08-18
Condition(s) studied
Rectal CancerCancer of RectumCancer of the RectumNeoplasms, RectalRectal TumorsRectum CancerRectum Neoplasms
Study summary
Neoadjuvant therapy has been widely applied to locally advanced rectal cancer. However, about 50% of patients receiving this therapy do not respond well as evidenced by the fact that their T or N stages are not effectively decreased judged by postoperative pathological examination. The purpose of this trail is to identify the biomarkers (from within patients' tumor mass before neoadjuvant therapy) to predict resistance to neoadjuvant therapy. These biomarkers can help stratify neoadjuvant-resistant patients towards surgery while avoiding unnecessary chemoradio-based neoadjuvant therapy.
Eligibility
Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria:
* Histopathology proved to be adenocarcinoma of the rectum.
* The edge of tumor is within 12cm of anus margin.
* According to the eighth edition of AJCC TNM staging standard ,that staging for Ⅱ-Ⅲ period, as T3-T4, N0 or any T, N1-2.
* There is no history of chemotherapy, radiotherapy or immunotherapy before neoadjuvant therapy.
* Understand and agree to sign the informed consent for the study.
Exclusion Criteria:
* With intestinal obstruction or impending obstruction, or perforation.
* With other malignancies occurred within 5 years.
Primary outcome measure(s)
Comparing gene expression differences between poor response group and complete response group by using RNA sequencing. — 6 months Using RNA-seq sequencing method to obtain the whole genome transcription profiles of the poor response group and complete response group, and compare the gene expression differences between these two groups.
Trial sites (2)
Facility
City
Region
Status
Wuhan Union Hospital
Wuhan
Hubei
Recruiting
Hubei Cancer Hospital
Wuhan
Hubei
Not Yet Recruiting
More Union Hospital, Tongji Medical College, Huazhong University of Science and Technology trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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