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Clinical trial register · China

Chronic Hepatitis b Trials in China, 2026

Every study on the ClinicalTrials.gov registry that lists a site in China and is open, about to open, active-but-closed, or enrolling by invitation. Filter it, cite it, and take it away as a file.

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Source: ClinicalTrials.gov, U.S. National Library of Medicine. Complete coverage โ€” all 19052 matching records held by the registry are in this view. Synced 22 Sep 2026, 11:10 UTC
19052
Studies in scope
all four open statuses
11786
Recruiting now
open to new participants
2009
Lead sponsors
across recruiting studies
Top sites
Beijing 22 Guangzhou 18 Chongqing 15 Shanghai 10 Fuzhou 9
Narrow the registerReset
Recruitment status
Phase
Lead sponsor
Ausper Biopharma Co., Ltd.8 Chia Tai Tianqing Pharmaceutical Group Co., Ltd.3 Fujian Akeylink Biotechnology Co., Ltd.3 Beijing 302 Hospital3 The Second Affiliated Hospital of Chongqing Medical University3
Site location
Beijing22 Guangzhou18 Chongqing15 Shanghai10 Fuzhou9
All 61 locations
Target enrolment
to

Chronic Hepatitis b trials in China

60 of 19052 studies
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Status
Study
Lead sponsor
Phase
Enrol
Chinese sites
Start
Not yet open
Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Characteristics of ACT500 in Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease Complicated With Chronic Hepatitis B
NCT07589400Metabolic Dysfunction-associated Steatotic Liver Disease, Chronic Hepatitis b
DrugACT500
Xiamen Amoytop Biotech Co., Ltd.
Phase 1
24
Beijing, Shanghai, รœrรผmqi, Xiamen
2026-10-30
Not yet open
Clinical Trial of TQA3605 Tablet in Combination With Nucleos(t)Ide Analogues(NAs) Versus NAs Alone for the Treatment of Patients With Chronic Hepatitis B Virus Infection Who Have Undergone Treatment and Exhibit Low Viral Load or Poor Response
NCT07797231Chronic Hepatitis B
DrugsTenofovir Alafenamide Fumarate·Tenofovir Disoproxil Fumarate·Entecavir
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Phase 3
930
Hefei, Wuhu, Beijing, Chongqing, Fuzhou, Xiamen, Lanzhou, Wuwei
2026-09
Not yet open
Sequential PD-1 Antibody and Pegylated Interferon Therapy for Nucleos(t)Ide Analogue-suppressed Chronic Hepatitis B
NCT07809165Chronic Hepatitis B
DrugsPegylated Interferon-ฮฑ 2b·Sintilimab
Beijing 302 Hospital
Not applicable
60
Jinan, Taiyuan, Xi'an
2026-09
Not yet open
A Study on the Consistency Evaluation of Digital PCR Technology for Quantitative Detection of HBV Nucleic Acid
NCT07684209Chronic Hepatitis b
Beijing Municipal Administration of Hospitals
Observational
200
Beijing
2026-08-01
Recruiting
Study of GST-HG131&141 Tablets Compared With Placebo in Patients With Chronic Hepatitis B
NCT07709520Chronic Hepatitis B
DrugGST-HG141
Fujian Akeylink Biotechnology Co., Ltd.
Phase 2
80
Beijing
2026-07-10
Recruiting
A Clinical Study Evaluating the Pharmacokinetic Characteristics and Safety of AHB-137 Injection in Participants With Mild to Moderate Liver Dysfunction and Those With Normal Liver Function.
NCT07600788Chronic Hepatitis B
DrugAHB-137
Ausper Biopharma Co., Ltd.
Phase 1
32
Chongqing, Zhengzhou, Shanghai, Chengdu, Hangzhou
2026-07-09
Recruiting
A Study to Evaluate AHB-137 Injection in Treatment-naรฏve Participants With Chronic Hepatitis B
NCT07635186Chronic Hepatitis B
DrugAHB-137
Ausper Biopharma Co., Ltd.
Phase 2
320
Beijing, Chongqing, Xiamen, Guangzhou, Jiangmen, Meizhou, Qingyuan, Shenzhen
2026-06-05
Not yet open
Union-FAST: An Intelligent-Agent Intervention to Increase Antiviral Treatment Uptake in Diagnosed-but-Untreated Hepatitis B Patients
NCT07520123Chronic Hepatitis B
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Not applicable
2,000
Wuhan
2026-05-01
Not yet open
A Study on the Pursuit of Sustained Clearance of HBsAg in Chronic Hepatitis B(CHB) Patients With Previous Interferon Treatment Using Pegylated Interferon Alpha
NCT07537387Chronic Hepatitis b
DrugPeg-IFNฮฑ-2b
xieqing
Observational
10,000
Shanghai
2026-04-30
Recruiting
SA1211 Injection Phase 1 Study
NCT07275918Chronic Hepatitis B
Suzhou Siran Biotechnology Co.,Ltd.
Phase 1
80
Changchun
2025-11-25
Active, closed
A Clinical Study of HT-101 and HT-102 in Patients With Chronic Hepatitis B Virus Infection
NCT07245953Chronic Hepatitis B
DrugsHT-101·HT-102
Suzhou HepaThera Biotech Co., Ltd.
Phase 2
60
Beijing, Fuzhou, Guangzhou, Qingyuan, Nanning, Zhengzhou, Nanjing, Zhenjiang
2025-11-05
Recruiting
A Study to Evaluate the Efficacy and Safety of AHB-137 Injection in Participants With Chronic Hepatitis B (CHB)
NCT07137910Chronic Hepatitis B
DrugAHB-137
Ausper Biopharma Co., Ltd.
Phase 2
200
Beijing, Jilin City, Chongqing, Xiamen, Guangzhou, Shenzhen, Nanning, Zhengzhou
2025-09-04
Active, closed
A Phase II Clinical Study of BW-20507 in Combination With PEG-IFNฮฑ for the Treatment of Hepatitis B
NCT07135349Chronic Hepatitis B
Shanghai Argo Biopharmaceutical Co., Ltd.
Phase 2
209
Hefei, Beijing, Sichuan, Chongqing, Fuzhou, Guangzhou, Shenzhen, Zunyi
2025-09-02
Recruiting
A Small Sample Prospective Clinical Study of Azvudine Tablets to Promote Clinical Cure in Patients With Chronic Hepatitis B
NCT07307586Chronic Hepatitis B, Azvudine
Zhigang Ren
Phase 3
120
Zhengzhou
2025-09-01
Recruiting
Long-term Follow-up Study to Evaluate Participants With Chronic Hepatitis B (CHB) Previously Treated With AHB-137 Injection
NCT07146100Chronic Hepatitis B
Ausper Biopharma Co., Ltd.
Observational
200
Hefei, Beijing, Chongqing, Fuzhou, Xiamen, Lanzhou, Foshan, Guangzhou
2025-08-28
Active, closed
Study of AHB-137 in Participants With Chronic Hepatitis B (CHB) Treated With Nucleos(t)Ide Analogues (NAs)(AUSHINE)
NCT07246889Chronic Hepatitis B
DrugAHB-137
Ausper Biopharma Co., Ltd.
Phase 3
577
Hefei, Beijing, Chongqing, Fuzhou, Xiamen, Lanzhou, Foshan, Guangzhou
2025-08-12
Not yet open
A Phase III Study to Evaluate the Efficacy and Safety of ZM-H1505R in Patients With CHB
NCT07095855Chronic Hepatitis B
Shanghai Zhimeng Biopharma, Inc.
Phase 3
1,300
Changchun
2025-08
Recruiting
To Evaluate the Efficacy, Safety and Population Pharmacokinetics of GST-HG141 in Patients With Chronic Hepatitis B (CHB) Who Have an Inadequate Response to Antiviral Drug Treatment
NCT07090759Chronic Hepatitis b
DrugGST-HG141
Fujian Akeylink Biotechnology Co., Ltd.
Phase 3
526
Hangzhou
2025-07-24
Active, closed
A Study to Evaluate the Antiviral Activity and Immune Response of AHB-137 Injection in Participants With Chronic Hepatitis B (CHB)
NCT06993480Chronic Hepatitis B
DrugAHB-137
Ausper Biopharma Co., Ltd.
Phase 2
20
Chongqing
2025-07-15
Active, closed
A Phase II/III of Hepenofovir Fumarate Tablets (HTS) for Chronic Hepatitis B
NCT07203118Chronic Hepatitis B
Xi'an Xintong Pharmaceutical Research Co.,Ltd.
Phase 2/3
1,444
Jilin City
2025-07-01
Recruiting
A Multicenter Study of AHB-137 Injection Combined With Other Hepatitis B Drugs
NCT07069569Chronic Hepatitis B
DrugsHepatitis B vaccine·PEG-IFNฮฑ·AHB-137
Ausper Biopharma Co., Ltd.
Phase 2
200
Beijing, Chongqing, Fuzhou, Guangzhou, Shenzhen, Zunyi, Wuhan, Changchun
2025-06-08
Recruiting
Combined Use of Bacteroides Fragilis and BCAAs on HBsAg Clearance
NCT07257562Chronic Hepatitis B
DrugBranched-Chain Amino Acids
First Affiliated Hospital of Fujian Medical University
Observational
40
Fuzhou
2025-06-01
Not yet open
A Real-World Study of Antiviral Therapy in Children With Chronic Hepatitis B
NCT06926647HBV, Chronic Hepatitis b
DrugIFN-ฮฑ
Beijing 302 Hospital
Observational
2,000
Ankang, Anyang, Beihai, Beijing, Binzhou, Changzhi, Changzhou, Chengdu
2025-05-01
Not yet open
Effects of Peginterferon Consolidation Therapy on Hepatic cccDNA Dynamics in CHB Patients Achieving Clinical Cure.
NCT06920329Chronic Hepatitis b
Xiamen Hospital of Traditional Chinese Medicine
Not applicable
30
Xiamen
2025-04-20
Not yet open
Pegylated Interferon Alfa-2b in Reducing Relapse Rates After Nucleos(t)ide Analogue Withdrawal in HBeAg-negative CHB Patients with Low Level HBsAg
NCT06900166Chronic Hepatitis B
Huashan Hospital
Phase 4
360
Shanghai
2025-04-01
Recruiting
Hospital-Based Management of Patients With Chronic Hepatitis B Virus Infection
NCT06966908Chronic Hepatitis B
Third Affiliated Hospital, Sun Yat-Sen University
Observational
16,300
Guangzhou, Zhuhai
2025-01-03
Recruiting
MR Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B
NCT06779058Chronic Hepatitis B, Liver Fibrosis
Shengjing Hospital
Observational
600
Shenyang
2025-01-01
Recruiting
HBV-Specific TCR-T Cell Therapy Combined With Nucleos(t)Ide Analogues in Chronic Hepatitis B Patients
NCT06885710Chronic Hepatitis b
Changhai Hospital
Phase 1
19
Shanghai
2024-12-31
Active, closed
A Clinical Study of HT-101 and/or HT-102 in Patients With Chronic Hepatitis B Virus Infection
NCT07183306Chronic Hepatitis B
DrugsHT-101·HT-102
Suzhou HepaThera Biotech Co., Ltd.
Phase 1/2
86
Beijing, Xiamen, Guangzhou, Qingyuan, Shanghai, Chengdu
2024-12-30
Not yet open
An Exploratory Clinical Study Evaluating EPI-003 Injection for the Treatment of Chronic Hepatitis B
NCT06745973Chronic Hepatitis B
Epigenic Therapeutics, Inc
Phase EARLY_PHASE1
20
Shanghai
2024-12-20
Active, closed
Study to Evaluate the Efficacy and Safety of AHB-137 in Treatment-naive Participants With Chronic Hepatitis B (CHB)
NCT06829329Chronic Hepatitis B
DrugAHB-137
Ausper Biopharma Co., Ltd.
Phase 2
105
Chongqing, Fuzhou, Guangzhou, Changzhou, Zhenjiang, Hangzhou
2024-12-13
Active, closed
Evaluate TQ-A3334 Combined Nucleoside (Acid) Analogs in the First Treatment/Treatment of Chronic HBV Infection
NCT06706310Chronic Hepatitis B
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Phase 2
116
Chongqing, Guangzhou, Shenzhen, Liuzhou, Wuhan, Changsha, Wuxi, Changchun
2024-12-04
Not yet open
Study of EPI-003 in Select Nucleos(t)Ide Analogue-Treated, Chronic Hepatitis B Patients
NCT06661148Chronic Hepatitis B, HBV (Hepatitis B Virus)
Epigenic Therapeutics, Inc
Phase 1
36
Hong Kong
2024-12-01
Recruiting
Research on Clinical Recovery and Maintenance Strategies for CHB
NCT06803368Chronic Hepatitis b, Hepatitis B Vaccine
Beijing Municipal Administration of Hospitals
Not applicable
285
Beijing
2024-11-01
Recruiting
Exploring the Genome-wide Association Study of the Population With Clinical Cure Advantage in the Treatment of Chronic Hepatitis B With Long-acting Interferon
NCT06696664Chronic Hepatitis B
DrugPEG-IFNฮฑ
Minghui Li
Observational
120
Beijing
2024-08-01
Recruiting
A Multicenter, Randomized, Open, Parallel-designed Study to Evaluate the Efficacy and Safety of HRS-5635 Injection Alone or in Combination With Other Agents in Patients Treated for Chronic Hepatitis B
NCT06425341Chronic Hepatitis B
DrugsHRS-5635·PEG-IFNฮฑ
Fujian Shengdi Pharmaceutical Co., Ltd.
Phase 2
369
Guangzhou
2024-06-06
Recruiting
Observation Study on Reducing the Risk of Liver Cancer Associated With Hepatitis B (Zhiyuan) Project.
NCT07169656Chronic Hepatitis b
DrugPeginterferon ฮฑ-2b
The First Affiliated Hospital of Zhengzhou University
Observational
15,000
Anyang, Guangzhou, Hebi, Jiaozuo, Jiayuguan, Jinan, Jiyuan, Kaifeng
2024-06-03
Recruiting
ASC22 Combined With Peg-IFNa in Achieving Functional Cure in Patients With Chronic Hepatitis B Virus Infection
NCT07573943Chronic Hepatitis b
The Second Affiliated Hospital of Chongqing Medical University
Phase 4
120
Chongqing
2024-05-21
Active, closed
The Treatment of PD-1 Antibody Combined With Peg-IFNฮฑ in NAs-suppressed CHB Patients
NCT06357806Chronic Hepatitis B
DrugsPeg-IFNฮฑ-2b·Sintilimab
Beijing 302 Hospital
Not applicable
45
Beijing
2024-05-17
Recruiting
Pegylated Interferon ฮฑ in Previously Interferon-treated CHB๏ผˆLeading Study๏ผ‰
NCT06323681Chronic Hepatitis b
Qing XIe
Not applicable
2,016
Shanghai
2024-02-04
Recruiting
Molecular Characteristics of Hepatitis B Virus Integration, Mutation, and Drug Resistance
NCT06779864Chronic Hepatitis B
Beijing Friendship Hospital
Observational
2,000
Beijing
2024-02-01
Active, closed
Study to Evaluate Immunogenicity and Safety of TVAX-008 Injection in Non/Treated Chronic Hepatitis B Patients With HBsAgโ‰ค20IU/ml or HBsAg Negative Without Serological Conversion
NCT07204236Chronic Hepatitis B
DrugTVAX-008
Grand Theravac Life Sciences (Nanjing) Co., Ltd.
Phase EARLY_PHASE1
20
Jinan
2024-01-18
Recruiting
Efficacy and Safety of Antiviral Therapy With Peg-interferon for Chronic Hepatitis B Complicated With Nonalcoholic Fatty Liver Disease๏ผˆOCEAN PROJECT๏ผ‰
NCT06368882Nonalcoholic Fatty Liver Disease, Chronic Hepatitis b
First Affiliated Hospital of Wenzhou Medical University
Phase 4
1,500
Ningbo, Ruiโ€™an, Wenzhou, Yueqing
2024-01-01
Recruiting
A Randomized, Double-blind, Placebo-controlled Phase IIa Clinical Study to Evaluate the Safety and Efficacy of GST-HG131 Tablets in Patients With Chronic Hepatitis B
NCT06263959Chronic Hepatitis B
Fujian Akeylink Biotechnology Co., Ltd.
Phase 2
45
Beijing
2023-12-26
Active, closed
A Clinical Study of TQA3605 Tablets Monotherapy or in Combination With Nucleoside (Acid) Analogues in Treatment Naive and Treated Patients With Chronic Hepatitis B
NCT06150014Chronic Hepatitis b
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Phase 1/2
88
Chongqing, Xi'an
2023-12-07
By invitation
Clinical Study of Antiviral Therapy Combined With Novel Immunotherapy for CHB in Adults
NCT06777173Chronic Hepatitis b, Immunotherapy
Beijing Ditan Hospital
Not applicable
180
Beijing
2023-12-01
Recruiting
A Novel Combination Therapeutic Strategy Aiming to Functional Cure for Chronic Hepatitis B Virus Infection (Sustained HBsAg Loss) (B)
NCT05771402Chronic Hepatitis b, Anti-PD-1 Antibody, Peg-IFNฮฑ
DrugPEG-IFNฮฑ
The Second Affiliated Hospital of Chongqing Medical University
Phase 2
120
Chongqing
2023-10-10
Recruiting
A Novel Combination Therapeutic Strategy Aiming to Functional Cure for Chronic Hepatitis B Virus Infection (Sustained HBsAg Loss) (A)
NCT05769816Chronic Hepatitis b, Anti-PD-1 Antibody
DrugETV,TDF,TAF
The Second Affiliated Hospital of Chongqing Medical University
Phase 2
120
Chongqing
2023-10-10
Recruiting
Clinical Outcomes of HBeAg-negative CHB Patients With Indeterminate Phase
NCT05661786Chronic Hepatitis b
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Observational
4,500
Changzhou, Huai'an, Nanjing, Suqian, Suzhou
2022-12
Active, closed
The Effectiveness and Safety of TMF in the Treatment of Chronic Hepatitis B Patients With Normal ALT.
NCT05797714HBV Infection, Chronic Hepatitis b
DrugTenofovir Amibufenamide๏ผˆTMF๏ผ‰
Ruijin Hospital
Not applicable
200
Changsha, Beijing, Dongyang, Fuyang, Hangzhou, Lishui, Nanchang, Nanjin
2022-06-08
Recruiting
Risk Factors for Hepatic Inflammation, Fibrosis and Prognosis in Patients With CHB and NAFLD
NCT05766449Chronic Hepatitis b, Non-alcoholic Fatty Liver Disease
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Observational
1,000
Nanjing
2022-06-01
By invitation
A Follow-up Study of Peginterferon Alfa-2b Combined With TDF in Patients With Chronic Hepatitis B
NCT06707922Chronic Hepatitis B
DrugsTenofovir Alafenamide Fumarate·Peginterferon ฮฑ-2b
Xiamen Amoytop Biotech Co., Ltd.
Not applicable
350
Beijing, Changsha, Chengdu, Fuzhou, Guangzhou, Guanzhou, Harbin, Hefei
2022-03-18
Active, closed
A Study of LP-128 Capsules in Healthy Subjects
NCT05130567Chronic Hepatitis b
Guangzhou Lupeng Pharmaceutical Company LTD.
Phase 1
104
Guangzhou
2021-11-19
Active, closed
Tenofovir Alafenamide Switching Therapy in Kidney or Liver Transplant Recipients With Chronic HBV Infection
NCT05410496Safety Issues, Chronic Hepatitis B, Transplant Recipient
DrugTenofovir alafenamide
Taichung Veterans General Hospital
Phase 4
52
2021-06-22
Recruiting
Safety and Efficacy of TAF to Prevent MTCT of HBV in Middle/Late Pregnancies With High HBV DNA Load
NCT05466071Chronic Hepatitis b, Pregnancy Related
Xingfei Pan
Observational
200
Guangzhou
2021-06-01
Recruiting
Study of Tenofovir Alafenamide in HBV-Infected Pregnant Women
NCT05853718Chronic Hepatitis b, Tenofovir Alafenamide Fumarate
First People's Hospital of Hangzhou
Phase 4
50
Hangzhou
2021-05-06
Recruiting
Long-term Outcomes of Anti-viral Therapies in Patients With Chronic Viral Hepatitis B
NCT04896255Chronic Hepatitis b
Huashan Hospital
Observational
33,000
Shanghai
2020-09-09
Active, closed
Prediction System of Clinical Endpoint Events for Chronic Hepatitis B Patients
NCT03777969Chronic Hepatitis b
Beijing Friendship Hospital
Observational
2,000
Beijing, Guangzhou, Wuxi, Shanghai, Hangzhou
2018-06-29
Recruiting
Follow-up of Chronic Hepatitis B Patients With Comorbid Nonalcoholic Fatty Liver Disease
NCT02863757Chronic Hepatitis B, Nonalcoholic Fatty Liver Disease
Humanity and Health Research Centre
Observational
1,500
Hong Kong
2016-08-01
Recruiting
Therapeutic Effects and Long-term Follow-up After Ending Nucleos(t)Ide Analogs Therapy in Chronic Hepatitis b
NCT02883647Chronic Hepatitis b
DrugsTenofovir·Entecavir
Third Affiliated Hospital, Sun Yat-Sen University
Observational
100
Guangzhou
2014-01-01
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Cite this view

Priya Life Science (2026). Clinical trial register: studies with a Chinese investigative site, filtered. Derived from ClinicalTrials.gov. Retrieved 27 September 2026. https://priyalifescience.com/clinical-trials-china/condition/chronic-hepatitis-b

Query this register directly
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About this register

This register is built from ClinicalTrials.gov, the trial registry run by the U.S. National Library of Medicine. It includes every study on the registry that lists at least one investigative site in China and is recruiting, not yet recruiting, active but no longer recruiting, or enrolling by invitation: 19,052 studies in total at the last sync on 22 Sep 2026, 11:10 UTC. The full list can be downloaded as CSV or queried as JSON through the register API.

This page shows the 60 of those studies listing the condition Chronic Hepatitis b.

How many Chronic Hepatitis b trials are recruiting in China?

31 of the 60 studies on this page are recruiting new participants as of the 22 Sep 2026, 11:10 UTC sync. A further 12 have not yet opened recruitment, 15 are active but closed to new participants, and 2 are enrolling by invitation only. Eligibility for any study is decided by its study team.

Summary by phase

Studies by phase (Chronic Hepatitis b), 60 studies
PhaseStudiesRecruitingShare
Observational171328.3%
Phase 213821.7%
Not applicable9215%
Phase 16310%
Phase 3528.3%
Phase 4538.3%
Phase 1/2203.3%
Phase EARLY_PHASE1203.3%
Phase 2/3101.7%

Most active sponsors

Lead sponsors with the most studies (Chronic Hepatitis b)
Lead sponsorStudiesRecruiting
Ausper Biopharma Co., Ltd.85
Beijing 302 Hospital30
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.30
Fujian Akeylink Biotechnology Co., Ltd.33
The Second Affiliated Hospital of Chongqing Medical University33
Beijing Friendship Hospital21
Beijing Municipal Administration of Hospitals21
Epigenic Therapeutics, Inc20
Huashan Hospital21
Suzhou HepaThera Biotech Co., Ltd.20
Listing here is informational and not medical advice; eligibility is determined by each study team. See also the Ireland, UK, EU, USA and India registers.