Opioid Use DisorderOpioid Abuse or DependenceOpioid WithdrawalPolysubstance Drug Use (Indiscriminate Drug Use)Polysubstance Abuse
Study summary
Unregulated opioids remain a leading driver of preventable mortality and potential years of life lost in Canada. Emergency departments (EDs)-open 24/7 and frequently accessed by people who use drugs-offer critical opportunities to reverse toxicity, mitigate harm, and initiate treatment. Yet, high quality evidence to guide ED care for patients with opioid poisoning and concomitant opioid dependence or opioid use disorder is limited. The investigators aim to establish a pan Canadian registry of patients presenting to EDs with opioid poisoning to generate timely, practice informing evidence. The investigators will create the Canadian Emergency Department Research Network (CEDRN) Opioid Registry across participating EDs nationwide. Using automated screening of electronic health records (EHRs), the investigators will identify consecutive patients of all ages with suspected or confirmed opioid poisoning at their index ED visit. The project's objectives are to establish a pan-Canadian registry of Emergency Department patients presenting with opioid poisoning, harmonize data collection across participating sites, describe variations in patient characteristics, clinical practice and outcomes, and derive a clinical decision rule to predict the risk of dying within 60 days. The expected outcomes include advancing healthcare delivery, improving patient and provider experiences, and enhancing population health and health system sustainability for individuals with opioid poisoning. This research is crucial for addressing the opioid crisis in Canada and has the potential to significantly impact patient care and outcomes.
Eligibility
Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria:
1. All patients who arrive at the emergency department with the following emergency department discharge diagnosis:
* Percocet Overdose
* Oxycontin Overdose
* Oxycodone Overdose
* Opioid Overdose or Intoxication
* Methadone Overdose
* Heroin Overdose
* Fentanyl Overdose
* Codeine Overdose
* Carfentanil Overdose
* Opioid Withdrawal
2. All patients who arrive at the emergency department who had the following medication ordered in the present visit or previous hospital visits in the past 2 years:
* Buprenorphine
* Buprenorphine-naloxone
* Methadone - Past ED or IP encounter
* Kadian/Morphine long-acting
* Naloxone
* Naloxone kit
3. All patients who arrive at the emergency department with the following impatient discharge diagnosis:
* Opioid use disorder (mild/moderate/severe, abuse/dependence), or opioid-related disorders
* Adverse effect, and poisoning by polysubstance use
* Opioid intoxication or withdrawal
* Intoxication or withdrawal (from any substance, including unspecified ones)
* Adverse effect, and poisoning by opioids, benzodiazepines, other antiepileptic and sedative-hypnotic drugs, and unspecified drugs
* Any psychoactive substance abuse resulting in intoxication, withdrawal, or any adverse effects
Primary outcome measure(s)
Proportion of patients who received opioid agonist therapy (methadone, buprenorphine/naloxone, extended release buprenorphine injection, slow-release oral morphine). — From date of emergency department arrival date until they are discharged from the emergency department (usually within the first 72 hours since arrival time). Number of patients that were administered any of the following types of opioid agonist therapy during their visit to the emergency department.
Trial sites (1)
Facility
City
Region
Status
Vancouver General Hospital
Vancouver
British Columbia
Recruiting
More University of British Columbia trials in Canada
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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