Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones

Condition(s) studied

Investigational drug(s) / intervention(s)

Potassium Citrate: 20 mEq Kcit twice a day (40 mEq daily

Sodium Bicarbonate: 650 mg sodium bicarbonate twice a day (35.2 mEq daily)

Study summary

Kidney stones affect 1 in every 11 people in the US each year. In patients with kidney stones who are prescribed medications for stone management, only 30.2% are adherent to a medication regime and even fewer, only 13.4 % are adherent with citrate medications.

Prescription potassium citrate can be expensive for many patients, leading to non-compliance. Sodium bicarbonate is a potential medication alternative that is cheaper and can potentially alkalinize the urine and/or decrease the risk of future kidney stones. However, efficacy of alternatives to potassium potassium citrate are not well studied.

This study seeks to evaluate sodium bicarbonate and assess its ability to alkalinize urine in a cohort of patients with kidney stones and compare this to prescription potassium citrate.

Eligibility

Primary outcome measure(s)

• Change in 24-Hour Urinary Citrate Excretion from 24-Hour Urine Collection — 14 days
  Change in 24-hour urinary citrate excretion measured from 24-hour urine collections obtained at baseline and after intervention. To determine if sodium bicarbonate is not significantly worse than potassium citrate by more than a clinically acceptable margin of -10 Unit: mg/day

Trial sites (6)

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