Muscular AtrophyInsulin ResistanceMuscle Protein Synthesis
Investigational drug(s) / intervention(s)
Bedrest
Bedrest: 5 days of strict bedrest. Participants are allowed to sit up in bed, but will perform any bathing or bathroom activities in a wheelchair.
Study summary
The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest. The main questions it aims to answer are:
How much do skeletal muscle volume, strength, and fatigue resistance decline during bedrest? How much does whole-body insulin sensitivity change during bedrest? How do mitochondrial function and protein synthesis change during bedrest?
Participants will undergo the following tests before and after a free-living control period and before and after a 5 day period of strict horizontal bedrest:
* Magnetic resonance imaging of the thigh muscles
* Strength testing of the thigh muscles
* Insulin sensitivity testing in response to a mixed meal
* Exogenous glucose oxidation in response to a mixed meal
* Muscle biopsies from the thigh muscles
* Blood samples
Eligibility
Sex
ALL
Min age
18 Years
Max age
30 Years
Healthy volunteers
Accepted
Inclusion Criteria:
* Males and females 18-30 years
* BMI between 18.5-28 kg/m2
* Weight stable (within ±2kg for 6 months)
* Generally healthy as assessed by medical and physical activity questionnaires
* recreationally active
Exclusion Criteria:
* a BMI \< 18.5 and \> 28 kg/m2
* the use of insulin to control blood glucose levels
* a history of any cardiovascular, respiratory, metabolic diseases, neuromuscular or bone-wasting diseases
* the use of any medication that may affect muscle protein turnover (e.g. androgen or anabolic hormone therapy, chemotherapy)
* a (family) history of thrombosis, platelet or coagulation disorders, or antiplatelet therapy and the use of anticoagulant medications
* the presence of any unremoved, or partially removed metals underneath the skin
* a history of head or eye injury involving metal fragments
* have some type of implanted electrical device (such as a cardiac pacemaker or neurostimulator)
* have implanted metal objects as a result of surgery, such as artificial joints, aneurysm clips, metal staples
* are, or may be, pregnant
* are wearing metal braces on their teeth.
Primary outcome measure(s)
Quadriceps muscle volume — Day 0, and 5 Quadriceps muscle volume will be assessed by magnetic resonance imaging.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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